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• scMultiome (snRNA + snATAC) data of 26 regionally sampled GBM tissue from 6 patients

  This dataset contains snRNA-seq data of 26 regionally sampled GBM tissue (peritumoral region, tumor edge, and tumor core). Regionally sampled GBM patient tissue was dissociated and nuclei were processed unsorted or by sorting with 7AAD to remove debris and dead cells. Single-nuclei suspension was prepared following the nuclei isolation protocol Single Cell Multiome ATAC + Gene Expression Sequencing protocol using Chromium Nuclei Isolation Kit. Single-nuclei suspension was prepared following the nuclei isolation protocol Single Cell Multiome ATAC + Gene Expression Sequencing protocol using Chromium Nuclei Isolation Kit, nuclei were barcoded and RNA and ATAC libraries were constructed, allowing for simultaneous capture of transcriptome and epigenome from the same cells.

  Dataset EGAD50000001838

• Whole Exome Sequencing of Human Gastro-esophageal Cancer PDXs

  The dataset includes 51 whole exome sequencing datasets generated using Illumina paired-end sequencing technology. These data derive from 26 patient-derived xenograft (PDX) tumors and their matched normal tissues, which consist of either normal gastric mucosa or blood samples. In one case (GTR0607), the matched normal tissue data are unavailable. As a result, the dataset comprises 102 FASTQ files, providing raw sequencing reads for comprehensive genomic analysis.

  Dataset EGAD50000001407

• Expression data from the Neo-CheckRay trial

  ER+/HER2- early breast cancer were treated with neoadjuvant immune-modulating SBRT and anti-CD73. The RNAseq dataset contains fastq files for 234 samples corresponding to 134 patients. There are 208 breast cancer samples, taken at screening (N=136) or week 6 (N=76). In addition, there are 26 lymph node samples taken at screening.

  Dataset EGAD50000002552

• Gut metagenomic data of 2,338 Pinggu adults

  Here we exploited a Han Chinese population-based cohort with extensive host metadata established in the Pinggu (PG) district of Beijing, and investigated gut microbiota from 2,338 adults (26-76 years) by metagenomic sequencing, revealing associations of the gut microbiota with sex, sex hormones, age, and a number of clinical and metabolic parameters.

  Study EGAS00001004820

• WES of melanoma tumors treated with combined immune checkpoint blockade

  This study of pre-treatment melanoma tumor samples from patients subsequently treated with combined anti-CTLA-4 and anti-PD-1 checkpoint blockade sought to identify genomic biomarkers of response to therapy. A total of 26 tumor and matched normal samples underwent whole exome sequencing.

  Study EGAS00001003857

• WGS Fastq files from the CPC-Gene project in support of PRAD-CA, DCC Release 26

  PRAD-CA, DCC Release 26 : This dataset contains fastq files with Whole genome sequencing data for the CPC-Gene Project. Data from each sample was generated using multiple whole genome libraries and sequenced across multiple runs

  Dataset EGAD00001003706

• Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancer

  Gene expression profiles of single cells from 26 chemo-naïve and IDS tumor tissue and ascites samples from 17 HGSC patients

  Study EGAS50000000607

• dataset1

  Contains 14 control samples and 26 case samples.

  Dataset EGAD00001008576

• Federated EGA

  Federated EGA Federated EGA Index Overview Map of FEGA status across the world Current status of the FEGA Network Documentation Overview Federated EGA is a global network of repositories enabling secure discovery and access to sensitive human data. Our vision is to accelerate scientific discovery and healthcare breakthroughs by creating the go-to worldwide sensitive human data resource. Our values are: Privacy & Trust: Ensuring privacy of data subjects, security of services and acting with integrity to build community trust.FAIRness: Driving reuse of data through standardisation of metadata and clear access policies.Diversity: Expanding our network and representing global diversity in the data we host to bring benefits worldwide. Federated EGA - European by name, global by nature Federated EGA collaborates with European and global initiatives (GA4GH, ELIXIR, 1+ Million Genomes Framework, GDI), demonstrating that a network for transnational discovery of and access to human data is possible. By providing a solution to emerging challenges around secure and efficient management of human omics and associated data, the FEGA Network fosters data reuse, enables reproducibility, and accelerates biomedical research. For general enquiries or to request more information about Federated EGA, please send an email to fega-info [at] lists [dot] ega-archive [dot] org. Read more about the Federated EGA in our commentary in Nature Genetics! Learn more about joining the Federated EGA Network in our onboarding documentation. Map of FEGA status across the world Current status of the FEGA Network Node Description Joined CEGA Central EGA is managed by the Centre for Genomic Regulation (CRG) and EMBL-EBI. The EGA has been a trusted repository for sensitive data since 2008. CEGA coordinates the FEGA network, hosts central services and the EGA catalogue. 2022 Finland FEGA Finland is hosted by CSC - IT Center for Science Ltd., which is the national ELIXIR Node in Finland. CSC is a state-owned company specialising in providing high-quality IT infrastructure and services for Finnish higher education and research. 2022 Germany The German Human Genome-Phenome archive (GHGA) is part of the German National Research Data Infrastructure (NFDI). It is coordinated by the German Cancer Research Center (DKFZ) and includes over 20 academic partners. 2022 Norway FEGA Norway is a service by ELIXIR Norway, the Norwegian node of the European organisation ELIXIR. University of Oslo as a partner institution in ELIXIR Norway is hosting the service relying on the TSD infrastructure for sensitive data. ELIXIR Norway is a consortium of 5 Norwegian universities and is coordinated by University of Bergen. 2022 Spain FEGA Spain is co-hosted by the Barcelona Supercomputer Center (BSC) and the Centre for Genomic Regulation (CRG), both part of ELIXIR Spain and the Spanish National Infrastructure for Personalised Medicine associated with Science and Technology (IMPaCT). 2022 Sweden FEGA Sweden is hosted by the National Bioinformatics Infrastructure Sweden (NBIS), which legally is part of Uppsala University. NBIS forms the bioinformatics platform at SciLifeLab and constitutes the Swedish node of the European organisation ELIXIR. 2022 Poland FEGA Poland is hosted by Biobank Lodz, which is part of University of Lodz. Biobank Lodz is an element of the infrastructure of the Regional Digital Medicine Centers established by the Medical Research Agency. 2022 Portugal FEGA Portugal is managed by BioData.pt, the distributed infrastructure for Life and Health data for Portugal. This entity is a non-profit association of 15 life sciences R&I organisations spread across the country, and the home of ELIXIR Node in Portugal. 2023 Canada Canadian Genome-phenome Archive is part of the Pan Canadian Genome Library, with the mandate to allow the secure and responsible sharing and analysis of Canadian genomic information. 2024 Switzerland Swiss FEGA is hosted by SIB Swiss Institute of Bioinformatics, which is the national ELIXIR Node in Switzerland, on behalf of the Swiss FEGA Partnership which includes 4 other key partners (ETH Zurich, Health 2030 Genome Center, Swiss Data Science Center and Switch). 2025 Documentation Title Version Description Mission, vision, values Federated EGA Mission, vision, values 1.0 The official Mission-Vision-Values statement for FEGA, produced and formally approved by the FEGA Strategic Committee in September 2025. Structure and Organisation Federated EGA Structure and Organisation 2.0 The structure of the FEGA network and service expectations, responsibilities and commitments. FEGA is organised into three tiers: Central EGA, FEGA Nodes and FEGA Affiliates. Strategic Committee Federated EGA Strategic Committee 1.1 Terms of reference for the FEGA Strategic Committee describe the purpose and objectives of the committee, which is to provide direction and strategic planning for the FEGA network. The committee receives input from, and provides feedback for the EGA Strategic Committee. Operations Committee Federated EGA Operations Committee 1.1 Terms of reference for the FEGA Operations Committee describe the purpose and objectives of the committee, which is to review operational performance and coordinate technical roadmaps of FEGA Nodes and Central EGA. The committee receives advice from, and provides operational reporting to the FEGA Strategic Committee. Guidelines Federated EGA Node Operations Guidelines 2.1 An overview of the operational areas which require resources in order to create a FEGA Node. The document is based on more than 15 years' experience of EMBL-EBI and CRG operating the EGA and initial expericences of the inaugural FEGA Nodes. The operational areas of responsability are in line with the FEGA Maturity Model, which guides establishment and operation of FEGA Nodes. Collaboration Federated EGA Node Collaboration Agreement 1.3 Nodes are welcome to make a copy of this current version of the CA to start its review with their legal teams and understand the responsibilities of joining FEGA. Nevertheless, this version (the one with a watermark) shall not be signed: the official version needs to be obtained from FEGA prior to signing through its official channels. Federated EGA Affiliate Collaboration Agreement 1.0 Affiliates are welcome to make a copy of this current version of the CA to start its review with their legal teams and understand the responsibilities of joining FEGA. Nevertheless, this version (the one with a watermark) shall not be signed: the official version needs to be obtained from FEGA prior to signing through its official channels.

  Documentation about/projects-and-funders/federated-ega

• Multi-omics datasets (WES, RNA-seq) of mesothelioma MIST4 study, a phase II PD-L1/VEGF blockage clinical trial

  This study comprises 26 mesothelioma patients with whole exome and RNA sequencing, designed to examine the efficacy and correlates of response to dual inhibition of programmed death-ligand 1 and vascular endothelial growth factor inhibition.

  Study EGAS50000001818