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Tubulointerstitial fibrosis is the histological hallmark of chronic kidney disease (CKD). Hypoxia and inflammation (i.e., interleukin (IL)-1β signalling) are independent mediators of tubulointerstitial fibrosis. However, the physiological response of human kidney tubular cells to IL-1β/IL-1RI signalling under the hypoxic conditions of CKD is poorly understood and remains a clinical imperative for therapeutic targeting. This study reports that hypoxia and IL-1β act in synergy to trigger cell cycle arrest/cellular senescence of ex vivo patient-derived primary proximal tubular epithelial cells (PTECs).
Study
EGAS00001007904
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Disease Variant Landscape of a Large Multiethnic Population of Moyamoya Patients by Exome Sequencing
Study
phs001700
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Heart Failure Network - Nitrate's Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction (HFN NEAT-BioLINCC)
Study
phs003548
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Heart Failure Network - Imaging from Nitrate's Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction (HFN NEAT-Imaging)
Study
phs004254
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Identifying autosomal recessive mutations causing neurological disorders
Study
EGAS00001000023
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Recording physiological history of cells with chemical labeling.
Study
EGAS50000000056
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deCODE Genetics study on genes contributing to nicotine dependence in humans
Study
phs000393
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Human Lung Tissue eQTL Study
Study
phs001745
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A New High-Throughput Sequencing-Based Technology to Study Heterochromatin Structure
Study
phs002202
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Multimodal Mapping of the Immune Landscape in Human Pancreatic Cancer
Study
phs002071