Study ID Alternative Stable ID Type
EGAS00001000036 Cancer Genomics

Study Description

Agilent whole exome hybridisation capture will be performed on genomic DNA derived from Multiple Myeloma patient DNA and matched normal DNA from the same patients. Two lanes of Illumina GA sequencing will be performed on the resulting exome libraries and mapped to build 37 of the human reference genome to facilitate the identification of novel cancer genes.

Study Datasets 3 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
Integrative Oncogenomics of Multiple Myeloma
Illumina Genome Analyzer II,Illumina HiSeq 2000 174
Multiple myeloma is an incurable plasma cell malignancy whose molecular pathogenesis is incompletely understood. We used whole exome sequencing, copy number profiling and cytogenetic to analyses 84 samples from 67 patients with myeloma. In addition to known myeloma genes, we identify new candidate genes, including truncations of SP140, ROBO1 and FAT3 and clustered missense mutations in EGR1. We find oncogenic mutations in cancer genes not previously implicated in myeloma, including SF3B1, ... (Show More)
Illumina Genome Analyzer II,Illumina HiSeq 2000 154
Myeloma case sample genotype using Affymetrix SNP6.0
Affymetrix_SNP6 19

Who archives the data?