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We propose to definitively characterise the somatic genetics of Osteosarcoma cancer through generation of comprehensive catalogues of somatic mutations by high coverage genome sequencing.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000147 Illumina HiSeq 2000 108
EGAD00001000646 Illumina HiSeq 2000 14
EGAD00001004163 HiSeq X Ten Illumina HiSeq 2000 22
EGAD00010000488 Affymetrix_SNP6- 7
Publications Citations
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.
Nat Genet 45: 2013 1479-1482
Mutational signatures of ionizing radiation in second malignancies.
Nat Commun 7: 2016 12605
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.
Nat Commun 8: 2017 15936
Recurrent rearrangements of FOS and FOSB define osteoblastoma.
Nat Commun 9: 2018 2150
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements.
Nat Genet 51: 2019 705-715
MYC amplifications are common events in childhood osteosarcoma.
J Pathol Clin Res 7: 2021 425-431
Epigenetic dysregulation from chromosomal transit in micronuclei.
Nature 619: 2023 176-183
Quantitative and qualitative mutational impact of ionizing radiation on normal cells.
Cell Genom 4: 2024 100499