Study

Signatures of mismatch repair deficiency in cancer genomes

Study ID Alternative Stable ID Type
EGAS00001000182 Whole Genome Sequencing

Study Description

DNA replication errors occurring in mismatch repair (MMR) deficient cells persist as mismatch mutations and predispose to a range of tumors. Here, we sequenced the first whole-genomes from MMR-deficient tumors and observed that mutation rates were drastically increased relative to MMR-proficient endometrial tumors.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001000641
DNA replication errors occurring in mismatch repair (MMR) deficient cells persist as mismatch mutations and predispose to a range of tumors. Here, we sequenced the first whole-genomes from MMR-deficient endometrial tumors.
Complete Genomics,Illumina HiSeq 2000 44

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