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Agilent whole exome hybridisation capture will be performed on genomic DNA derived from 50 osteosarcoma cancers and matched normal DNA from the same patients. Three lanes of Illumina GA sequencing will be performed on the resulting 100 exome libraries and mapped to build 37 of the human reference genome to facilitate the identification of novel cancer genes

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000107 Illumina Genome Analyzer II Illumina HiSeq 2000 114
EGAD00001000280 Illumina HiSeq 2000 112
EGAD00001004201 Illumina HiSeq 2000 Illumina HiSeq 2500 75
Publications Citations
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.
Nat Commun 8: 2017 15936
Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.
Cell 176: 2019 1282-1294.e20
MYC amplifications are common events in childhood osteosarcoma.
J Pathol Clin Res 7: 2021 425-431
Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA.
Nature 602: 2022 510-517
Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis.
Nat Commun 14: 2023 77