Study

Breast Cancer Exome Sequencing

Study ID Alternative Stable ID Type
EGAS00001000211 Cancer Genomics

Study Description

Agilent whole exome hybridisation capture will be performed on genomic DNA derived from 100 breast cancers of all subtypes and matched normal DNA from the same patients. Three lanes of Illumina GA sequencing will be performed on the resulting 200 exome libraries and mapped to build 37 of the human reference genome to facilitate the identification of novel cancer genes.

Study Datasets 4 datasets.

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Dataset ID Description Technology Samples
EGAD00001000110
Breast Cancer Exome Sequencing
Illumina Genome Analyzer II,Illumina HiSeq 2000 179
EGAD00001000133
The landscape of cancer genes and mutational processes in breast cancer
Illumina Genome Analyzer II,Illumina HiSeq 2000 199
EGAD00001000637
Insertion of processed pseudogenes is known to occur in the germline but has not previously been observed in somatic cells. Formation of pseudogenes could represent a new class of mutation in cancers and a new source of potential driver events.
Illumina Genome Analyzer II,Illumina HiSeq 2000 4
EGAD00001002697
Recurrent breast cancer is almost universally fatal. We characterize 170 patients locally relapsed or distant metastatic cancers using massively parallel sequencing. We identify that the relapse-seeding clone disseminates late from the primary tumor. TP53 and AKT1 appear to be enriched in ER-positive cancers predisposed to relapse. Mutation acquisition continues at relapse as the same mutation signatures continue to operate and new signatures, such as that caused by radiotherapy appear de novo. ... (Show More)
Illumina HiSeq 2000 9

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