Dataset

Genomic Evolution of Breast Cancer Metastasis and Relapse

Dataset ID Technology Samples
EGAD00001002697 Illumina HiSeq 2000 9

Dataset Description

Recurrent breast cancer is almost universally fatal. We characterize 170 patients locally relapsed or distant metastatic cancers using massively parallel sequencing. We identify that the relapse-seeding clone disseminates late from the primary tumor. TP53 and AKT1 appear to be enriched in ER-positive cancers predisposed to relapse. Mutation acquisition continues at relapse as the same mutation signatures continue to operate and new signatures, such as that caused by radiotherapy appear de novo. In 49% of cases we identify drivers mutations private to the relapse and these are sampled from a wider range of cancer genes, including SWI-SNF complex and JAK-STAT signaling.

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

ICGC Data Access Compliance Office
Contact person: helpdesk
Email: dcc-support [at] icgc [dot] org
Access information: https://docs.icgc.org/download/data-access/
More details: EGAC00001000010

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