Study

Genetic landscape of pediatric Infant Acute Lymphoblastic leukemia

Study ID Alternative Stable ID Type
EGAS00001000246 Whole Genome Sequencing

Study Description

We performed whole genome sequencing of tumor and normal DNA samples obtained from 22 infant ALL cases with MLL rearrangements. In addition, we sequenced 2 paired diagnostic-relapse samples. Using complementary pipelines, somatically acquired genetic changes were analyzed, including single nucleotide variations (SNVs), insertion/deletions, structural variations and copy number variations in the cancer genomes. In addition, exome sequencing was performed on paired diagnostic and normal DNA samples obtained from 20 cases of non-infant MLL rearranged leukemias and somatic mutations in the coding regions were identified.

Study Datasets 6 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000165
DATA FILES FOR SJINF
Illumina HiSeq 2000 46
EGAD00001001098
DATA FILES FOR SJINF RNASeq
Illumina HiSeq 2000 63
EGAD00001001245
DATA FILES FOR PCGP SJINF WES
Illumina HiSeq 2000 40
EGAD00001001432
PCGP Germline Study Whole Genome Sequencing
Illumina HiSeq 2000 1337
EGAD00001001433
PCGP Germline Study Whole Exome Sequencing
Illumina HiSeq 2000 906
EGAD00010000698
PCGP INF ALL SNP6
N/A

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