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Analysis_of_resistance_to_PLX4032

We have collected material from a patient who had BrafV600E mutant melanoma that wastreated with PLX4032. We have germline DNA from the patient and DNA and RNA fromdistinct lesions before and after treatment with PLX4032. We would like to exome sequencethese samples to gain a snap shot of the mechanisms of resistance that are operative.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001002191 Illumina HiSeq 2000 28
EGAD00001005278 Illumina HiSeq 2000 42
Publications Citations
Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts.
EMBO Mol Med 7: 2015 1104-1118
89
XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data.
BMC Bioinformatics 19: 2018 366
64