Analysis_of_resistance_to_PLX4032 - EGA European Genome-Phenome Archive

Study

Analysis of resistance to PLX4032

Study ID	Alternative Stable ID	Type
EGAS00001000415		Other

Study Description

We have collected material from a patient who had BrafV600E mutant melanoma that wastreated with PLX4032. We have germline DNA from the patient and DNA and RNA fromdistinct lesions before and after treatment with PLX4032. We would like to exome sequencethese samples to gain a snap shot of the mechanisms of resistance that are operative.

Study Datasets 2 datasets.

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Dataset ID	Description	Technology	Samples
EGAD00001002191	NA NA	Illumina HiSeq 2000	28
EGAD00001005278	We have collected material from a patient who had BrafV600E mutant melanoma that was treated with PLX4032. We have germline DNA from the patient and DNA and RNA from distinct lesions before and after treatment with PLX4032. We would like to exome sequence these samples to gain a snap shot of the mechanisms of resistance that are operative. . This dataset contains all the data available for this study on 2019-08-21. We have collected material from a patient who had BrafV600E mutant melanoma that was treated with PLX4032. We have germline DNA from the patient and DNA and RNA from distinct lesions before and after treatment with PLX4032. We would like to exome sequence these samples to gain a snap shot of the mechanisms of resistance that are operative. . This dataset contains all the data available for this study on 2019-08-21.	Illumina HiSeq 2000	42

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