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Genomic libraries will be generated from total genomic DNA derived from 4000 samples with Acute Myeloid Leukaemia. Libraries will be enriched for a selected panel of genes using a bespoke pulldown protocol. 64 Samples will be individually barcoded and subjected to up to one lanes of Illumina HiSeq. Paired reads will be mapped to build 37 of the human reference genome to facilitate the characterisation of known gene mutations in cancer as well as the validation of potentially novel variants identified by prior exome sequencing.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000747 Illumina HiSeq 2000 2734
EGAD00001003703 Illumina HiSeq 2000 Illumina HiSeq 2500 628
Publications Citations
Prediction of acute myeloid leukaemia risk in healthy individuals.
Nature 559: 2018 400-404
Integration of intra-sample contextual error modeling for improved detection of somatic mutations from deep sequencing.
Sci Adv 6: 2020 eabe3722
Unified classification and risk-stratification in Acute Myeloid Leukemia.
Nat Commun 13: 2022 4622