Diverse modes of genomic alterations in hepatocellular carcinoma

Hepatocellular carcinoma is the most prevalent type of liver cancer. We intended to study the genomic landscape of this disease. We conducted whole-genome, exome and transcriptome sequencing for 42 patients. We show diverse modes in which the HCC genome is affected in these patients, including well-known and novel mutations, structural variations, and Hepatitis B-virus integration into the genome.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

3 Datasets 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001000885	Exome read sequences for 30 tumor-normal pairs for the study "Diverse modes of genomic alterations in Hepatocellular Carcinoma".	Illumina HiSeq 2000	60
EGAD00001000886	RNA-Sequencing data (raw read sequences) for 23 samples, from 12 patients, for the study "Diverse modes of genomic alterations in Hepatocellular Carcinoma"	Illumina HiSeq 2000	23
EGAD00001001034	Whole genome data (Complete genomics platform) for the study EGAS00001000824		24

Publications	Citations
Diverse modes of genomic alteration in hepatocellular carcinoma. Jhunjhunwala S, Jiang Z, Stawiski EW, Gnad F, Liu J, Mayba O, Du P, Diao J, Johnson S, Wong KF, Gao Z, Li Y, Wu TD, Kapadia SB, Modrusan Z, French DM, Luk JM, Seshagiri S, Zhang Z. Genome Biol 15: 2014 436	76
Advances in genomic hepatocellular carcinoma research. Huang W, Skanderup AJ, Lee CG. Gigascience 7: 2018 None	22