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Whole genome and RNA sequencing of paediatric glioblastoma in the ICGC PedBrain project

Paediatric glioblastoma (pedGBM) is characterised by substantial intertumoural heterogeneity. In order to identify the genetic lesions underlying tumourigenesis, we analysed whole genomes and transcriptomes of pedGBMs and in vitro model systems by next generation sequencing. Novel fusions of the receptor tyrosine kinase MET lead us to investigate targeted therapy using MET inhibitors. This study is part of the International Cancer Genome Consortium PedBrain Tumor Project (ICGC PedBrain,

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001944 Illumina HiSeq 2500 42
EGAD00001002006 Illumina HiSeq 2500 115
Publications Citations
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.
Cancer Cell 32: 2017 520-537.e5
confFuse: High-Confidence Fusion Gene Detection across Tumor Entities.
Front Genet 8: 2017 137
Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells.
Nat Med 24: 2018 1204-1215
TelomereHunter - in silico estimation of telomere content and composition from cancer genomes.
BMC Bioinformatics 20: 2019 272
ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization.
Cell Rep 38: 2022 110216
Structural variants shape driver combinations and outcomes in pediatric high-grade glioma.
Nat Cancer 3: 2022 994-1011
Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors.
Nucleic Acids Res 52: 2024 2372-2388