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The BC Cancer Agency's Personalized Onco-Genomics Project

The BC Cancer Agency's Personalized Onco-Genomics (POG) Project involves molecular and clinical characterization of individual cancer patients to guide their treatment. The project aims to use whole genome and transcriptome data together with patient information to match treatments to cancer driver alterations and support clinical decision-making. Incorporating genomic data into decision-making should enable more rational development of treatment plans, facilitate enrollment into appropriate clinical trials and potentially identify less toxic and more effective therapeutic options.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001307 3
EGAD00001001308 MinION PromethION 3
EGAD00001001309 3
EGAD00001001310 2
EGAD00001001311 3
EGAD00001001655 3
EGAD00001001656 2
EGAD00001001657 3
EGAD00001001658 2
EGAD00001001876 4
EGAD00001001961 4
EGAD00001001962 3
EGAD00001001963 2
EGAD00001001964 3
EGAD00001001965 3
EGAD00001001966 PromethION 3
EGAD00001001967 2
EGAD00001001968 PromethION 2
EGAD00001001969 2
EGAD00001002017 3
EGAD00001002018 4
EGAD00001002019 2
EGAD00001002020 2
EGAD00001002021 3
EGAD00001002022 3
EGAD00001002023 2
EGAD00001002024 3
EGAD00001002025 3
EGAD00001002026 4
EGAD00001002027 3
EGAD00001002028 3
EGAD00001002029 3
EGAD00001002030 3
EGAD00001002031 3
EGAD00001002032 3
EGAD00001002033 3
EGAD00001002034 2
EGAD00001002035 3
EGAD00001002036 3
EGAD00001002037 2
EGAD00001002038 5
EGAD00001002039 3
EGAD00001002040 3
EGAD00001002041 3
EGAD00001002042 3
EGAD00001002043 3
EGAD00001002044 3
EGAD00001002045 2
EGAD00001002046 3
EGAD00001002047 3
EGAD00001002048 3
EGAD00001002049 2
EGAD00001002531 3
EGAD00001002532 3
EGAD00001002533 2
EGAD00001002534 3
EGAD00001002535 3
EGAD00001002536 3
EGAD00001002537 2
EGAD00001002538 3
EGAD00001002539 3
EGAD00001002540 3
EGAD00001002541 2
EGAD00001002542 3
EGAD00001002543 3
EGAD00001002544 3
EGAD00001002545 2
EGAD00001002546 2
EGAD00001002547 4
EGAD00001002548 2
EGAD00001002549 2
EGAD00001002550 3
EGAD00001002551 3
EGAD00001002552 2
EGAD00001002553 2
EGAD00001002554 2
EGAD00001002555 3
EGAD00001002556 3
EGAD00001002557 2
EGAD00001002558 2
EGAD00001002559 2
EGAD00001002560 2
EGAD00001002561 2
EGAD00001002562 2
EGAD00001002563 2
EGAD00001002564 3
EGAD00001002565 5
EGAD00001002566 2
EGAD00001002567 3
EGAD00001002568 2
EGAD00001002569 2
EGAD00001002570 2
EGAD00001002571 2
EGAD00001002572 2
EGAD00001002573 2
EGAD00001002574 2
EGAD00001002575 2
EGAD00001002576 2
EGAD00001002577 2
EGAD00001002578 2
EGAD00001002579 2
EGAD00001002580 2
EGAD00001002581 2
EGAD00001002582 2
EGAD00001002583 2
EGAD00001002584 2
EGAD00001002585 2
EGAD00001002586 2
EGAD00001002587 2
EGAD00001002588 2
EGAD00001002589 3
EGAD00001002590 2
EGAD00001002591 MinION 2
EGAD00001002592 2
EGAD00001002593 3
EGAD00001002594 2
EGAD00001002595 2
EGAD00001002596 2
EGAD00001002597 2
EGAD00001002598 2
EGAD00001002599 2
EGAD00001002600 2
EGAD00001002601 2
EGAD00001002602 2
EGAD00001002603 2
EGAD00001002604 2
EGAD00001002605 2
EGAD00001002606 2
EGAD00001002607 2
EGAD00001002608 2
EGAD00001002609 2
EGAD00001002610 2
EGAD00001002611 2
EGAD00001002612 2
EGAD00001002613 2
EGAD00001002614 2
EGAD00001002615 2
EGAD00001002616 2
EGAD00001002617 2
EGAD00001002618 2
EGAD00001002619 2
EGAD00001002620 2
EGAD00001002621 2
EGAD00001002622 3
EGAD00001002623 3
EGAD00001002624 2
EGAD00001002625 2
EGAD00001002626 2
EGAD00001002627 2
EGAD00001002628 3
EGAD00001002629 3
EGAD00001002630 2
EGAD00001002631 3
EGAD00001002632 2
EGAD00001002633 2
EGAD00001002634 2
EGAD00001002635 2
EGAD00001002636 2
EGAD00001002637 2
EGAD00001002638 2
EGAD00001002639 2
EGAD00001002640 2
EGAD00001002641 2
EGAD00001002642 2
EGAD00001002643 2
EGAD00001002644 2
EGAD00001002645 2
EGAD00001002646 2
EGAD00001002647 2
EGAD00001002648 2
EGAD00001002891 2
EGAD00001002972 2
EGAD00001002973 2
EGAD00001002974 2
EGAD00001002975 2
EGAD00001002976 2
EGAD00001002977 2
EGAD00001002978 2
EGAD00001002979 2
EGAD00001002980 2
EGAD00001002981 2
EGAD00001002982 3
EGAD00001002983 2
EGAD00001002984 2
EGAD00001002985 2
EGAD00001002986 2
EGAD00001002987 2
EGAD00001002988 2
EGAD00001002989 2
EGAD00001002990 3
EGAD00001002991 2
EGAD00001002992 2
EGAD00001002993 2
EGAD00001002994 2
EGAD00001002995 2
EGAD00001002996 2
EGAD00001002997 2
EGAD00001002998 3
EGAD00001002999 2
EGAD00001003000 2
EGAD00001003001 2
EGAD00001003002 2
EGAD00001003003 2
EGAD00001003004 2
EGAD00001003005 2
EGAD00001003006 2
EGAD00001003007 3
EGAD00001003008 2
EGAD00001003009 2
EGAD00001003010 2
EGAD00001003011 2
EGAD00001003012 2
EGAD00001003013 2
EGAD00001003014 3
EGAD00001003015 2
EGAD00001003016 2
EGAD00001003017 2
EGAD00001003018 2
EGAD00001003019 2
EGAD00001003020 2
EGAD00001003021 2
EGAD00001003022 3
EGAD00001003023 2
EGAD00001003024 2
EGAD00001003025 2
EGAD00001003026 2
EGAD00001003027 2
EGAD00001003028 2
EGAD00001003029 3
EGAD00001003030 2
EGAD00001003031 2
EGAD00001003032 2
EGAD00001003033 2
EGAD00001003034 2
EGAD00001003035 2
EGAD00001003036 2
EGAD00001003037 2
EGAD00001003038 2
EGAD00001003039 2
EGAD00001003040 2
EGAD00001003041 3
EGAD00001003042 2
EGAD00001003043 2
EGAD00001003044 2
EGAD00001003045 2
EGAD00001003046 3
EGAD00001003047 2
EGAD00001003048 2
EGAD00001003049 3
EGAD00001003050 2
EGAD00001003051 2
EGAD00001003052 2
EGAD00001003053 2
EGAD00001003054 2
EGAD00001003055 2
EGAD00001003056 PromethION 2
EGAD00001003057 2
EGAD00001003058 2
EGAD00001003059 2
EGAD00001003060 2
EGAD00001003061 2
EGAD00001003062 3
EGAD00001003063 2
EGAD00001003064 2
EGAD00001003065 2
EGAD00001003066 2
EGAD00001003067 2
EGAD00001003068 2
EGAD00001003069 2
EGAD00001003070 2
EGAD00001003071 2
EGAD00001003072 2
EGAD00001003073 2
EGAD00001003074 2
EGAD00001003075 2
EGAD00001003076 2
EGAD00001003077 2
EGAD00001003078 2
EGAD00001003079 2
EGAD00001003080 2
EGAD00001003081 2
EGAD00001003082 2
EGAD00001003083 2
EGAD00001003084 2
EGAD00001003085 2
EGAD00001003086 3
EGAD00001003087 2
EGAD00001003088 2
EGAD00001003089 2
EGAD00001003090 2
EGAD00001003091 2
EGAD00001003603 2
EGAD00001003604 2
EGAD00001003605 2
EGAD00001003606 3
EGAD00001003607 2
EGAD00001003608 2
EGAD00001003609 2
EGAD00001003610 2
EGAD00001003611 2
EGAD00001003612 2
EGAD00001003613 2
EGAD00001003614 2
EGAD00001003615 2
EGAD00001003616 2
EGAD00001003617 2
EGAD00001003618 2
EGAD00001003619 2
EGAD00001003620 2
EGAD00001003621 2
EGAD00001003622 2
EGAD00001003623 2
EGAD00001003624 3
EGAD00001003625 2
EGAD00001003626 2
EGAD00001003627 2
EGAD00001003628 2
EGAD00001003629 2
EGAD00001003630 2
EGAD00001003631 2
EGAD00001003632 2
EGAD00001003633 3
EGAD00001003634 2
EGAD00001003635 2
EGAD00001003636 2
EGAD00001003637 2
EGAD00001003638 2
EGAD00001003639 2
EGAD00001003640 2
EGAD00001003641 2
EGAD00001003642 2
EGAD00001003643 2
EGAD00001003644 2
EGAD00001003645 2
EGAD00001003646 2
EGAD00001003647 2
EGAD00001003648 2
EGAD00001003649 2
EGAD00001003650 2
EGAD00001003651 3
EGAD00001003652 2
EGAD00001003653 2
EGAD00001003654 2
EGAD00001003655 3
EGAD00001003656 2
EGAD00001003657 2
EGAD00001003658 PromethION 2
EGAD00001003659 2
EGAD00001003660 2
EGAD00001003661 2
EGAD00001003662 2
EGAD00001003663 2
EGAD00001003664 2
EGAD00001003665 3
EGAD00001003666 2
EGAD00001003667 2
EGAD00001003668 2
EGAD00001003669 2
EGAD00001003670 2
EGAD00001003671 3
EGAD00001003672 2
EGAD00001003673 PromethION 2
EGAD00001003674 2
EGAD00001003675 2
EGAD00001003676 2
EGAD00001003677 2
EGAD00001003678 2
EGAD00001003679 2
EGAD00001003680 2
EGAD00001003681 2
EGAD00001003682 2
EGAD00001003683 2
EGAD00001003684 2
EGAD00001003685 2
EGAD00001003686 2
EGAD00001003687 2
EGAD00001003688 2
EGAD00001003689 3
EGAD00001003690 1
EGAD00001003691 2
EGAD00001003692 2
EGAD00001003693 2
EGAD00001003694 2
EGAD00001003695 2
EGAD00001003696 2
EGAD00001003697 2
EGAD00001003698 2
EGAD00001003699 3
EGAD00001003700 2
EGAD00001003701 2
EGAD00001003702 2
EGAD00001003708 2
EGAD00001003709 2
EGAD00001003710 3
EGAD00001003711 2
EGAD00001003712 2
EGAD00001003713 2
EGAD00001003714 2
EGAD00001003715 2
EGAD00001003716 2
EGAD00001003717 2
EGAD00001003718 2
EGAD00001003719 2
EGAD00001003720 2
EGAD00001003721 2
EGAD00001003722 2
EGAD00001003723 2
EGAD00001003724 2
EGAD00001003725 3
EGAD00001003726 2
EGAD00001003727 2
EGAD00001003728 2
EGAD00001003729 2
EGAD00001003730 2
EGAD00001003731 2
EGAD00001003732 2
EGAD00001003733 2
EGAD00001003734 2
EGAD00001003735 2
EGAD00001003736 2
EGAD00001003737 2
EGAD00001003738 2
EGAD00001003739 2
EGAD00001003740 2
EGAD00001003741 2
EGAD00001003742 2
EGAD00001003743 2
EGAD00001003744 2
EGAD00001004596 2
EGAD00001004597 2
EGAD00001004598 2
EGAD00001004599 2
EGAD00001004600 2
EGAD00001004601 2
EGAD00001004602 2
EGAD00001004603 2
EGAD00001004604 2
EGAD00001004605 2
EGAD00001004606 MinION PromethION 2
EGAD00001004607 2
EGAD00001004608 2
EGAD00001004609 2
EGAD00001004610 2
EGAD00001004611 2
EGAD00001004612 2
EGAD00001004613 2
EGAD00001004614 2
EGAD00001004615 2
EGAD00001004616 2
EGAD00001004617 2
EGAD00001004618 2
EGAD00001004619 2
EGAD00001004620 2
EGAD00001004621 2
EGAD00001004622 3
EGAD00001004623 2
EGAD00001004624 2
EGAD00001004625 2
EGAD00001004626 2
EGAD00001004627 3
EGAD00001004628 2
EGAD00001004629 2
EGAD00001004630 2
EGAD00001004631 2
EGAD00001004632 2
EGAD00001004633 2
EGAD00001004634 2
EGAD00001004635 2
EGAD00001004636 2
EGAD00001004637 2
EGAD00001004638 2
EGAD00001004639 2
EGAD00001004640 2
EGAD00001004641 2
EGAD00001004642 2
EGAD00001004643 2
EGAD00001004644 2
EGAD00001004645 2
EGAD00001004646 3
EGAD00001004647 2
EGAD00001004648 2
EGAD00001004649 2
EGAD00001004650 2
EGAD00001004651 2
EGAD00001004652 2
EGAD00001004653 2
EGAD00001004654 2
EGAD00001004655 2
EGAD00001004656 2
EGAD00001004657 2
EGAD00001004658 2
EGAD00001004659 2
EGAD00001004660 2
EGAD00001004661 2
EGAD00001004662 2
EGAD00001004663 2
EGAD00001004664 2
EGAD00001004665 2
EGAD00001004666 2
EGAD00001004667 2
EGAD00001004668 2
EGAD00001004669 2
EGAD00001004670 2
EGAD00001004671 2
EGAD00001004672 2
EGAD00001004673 2
EGAD00001004674 2
EGAD00001004675 2
EGAD00001004676 2
EGAD00001004677 2
EGAD00001004678 2
EGAD00001004679 2
EGAD00001004680 2
EGAD00001004681 2
EGAD00001004682 2
EGAD00001004683 2
EGAD00001004684 2
EGAD00001004685 2
EGAD00001004686 2
EGAD00001004687 2
EGAD00001004688 2
EGAD00001004689 2
EGAD00001004690 2
EGAD00001004691 2
EGAD00001004692 2
EGAD00001004693 2
EGAD00001004694 2
EGAD00001004695 MinION PromethION 2
EGAD00001004696 2
EGAD00001004697 2
EGAD00001004698 2
EGAD00001004699 2
EGAD00001004700 2
EGAD00001004701 2
EGAD00001004702 2
EGAD00001004703 2
EGAD00001004704 2
EGAD00001004705 2
EGAD00001004706 2
EGAD00001004707 2
EGAD00001004708 2
EGAD00001004709 2
EGAD00001004710 2
EGAD00001004711 2
EGAD00001004713 2
EGAD00001004714 2
EGAD00001004715 2
EGAD00001004716 2
EGAD00001004717 2
EGAD00001004718 2
EGAD00001004897 2
EGAD00001004898 2
EGAD00001004899 2
EGAD00001004900 2
EGAD00001004901 2
EGAD00001004902 2
EGAD00001004903 2
EGAD00001004904 PromethION 2
EGAD00001004905 2
EGAD00001004906 2
EGAD00001004907 2
EGAD00001004908 2
EGAD00001004909 2
EGAD00001004910 2
EGAD00001004911 2
EGAD00001004912 2
EGAD00001004913 2
EGAD00001004914 2
EGAD00001004915 2
EGAD00001004916 2
EGAD00001004917 2
EGAD00001004918 2
EGAD00001004919 2
EGAD00001004920 2
EGAD00001004921 2
EGAD00001004922 2
EGAD00001004923 PromethION 3
EGAD00001004924 2
EGAD00001004925 2
EGAD00001004926 2
EGAD00001004927 2
EGAD00001004928 2
EGAD00001004929 2
EGAD00001004930 2
EGAD00001004931 2
EGAD00001004932 2
EGAD00001004933 2
EGAD00001004934 3
EGAD00001004935 3
EGAD00001004936 3
EGAD00001005763 PromethION 3
EGAD00001005823 2
EGAD00001005824 2
EGAD00001005825 2
EGAD00001005826 2
EGAD00001005827 2
EGAD00001005828 2
EGAD00001005829 2
EGAD00001005830 2
EGAD00001005831 2
EGAD00001005832 2
EGAD00001005833 2
EGAD00001005834 2
EGAD00001005835 2
EGAD00001005836 2
EGAD00001005837 2
EGAD00001005838 2
EGAD00001005839 2
EGAD00001005840 2
EGAD00001005841 2
EGAD00001005842 2
EGAD00001005843 2
EGAD00001005844 2
EGAD00001005845 2
EGAD00001005846 2
EGAD00001005847 2
EGAD00001005848 2
EGAD00001005849 2
EGAD00001005850 3
EGAD00001005851 2
EGAD00001005852 2
EGAD00001005853 2
EGAD00001005854 2
EGAD00001005855 2
EGAD00001005856 2
EGAD00001005857 2
EGAD00001005858 2
EGAD00001005859 2
EGAD00001005860 2
EGAD00001005861 2
EGAD00001005862 2
EGAD00001005863 2
EGAD00001005864 2
EGAD00001005865 2
EGAD00001005866 2
EGAD00001005867 2
EGAD00001005868 2
EGAD00001005869 2
EGAD00001005870 2
EGAD00001005871 2
EGAD00001005875 2
EGAD00001005876 2
EGAD00001005877 2
EGAD00001005878 2
EGAD00001005879 2
EGAD00001005880 2
EGAD00001005881 2
EGAD00001005882 2
EGAD00001005883 2
EGAD00001005884 2
EGAD00001005885 2
EGAD00001005886 2
EGAD00001005887 2
EGAD00001005888 2
EGAD00001005889 2
EGAD00001005890 2
EGAD00001005891 2
EGAD00001005892 2
EGAD00001005893 2
EGAD00001005894 2
EGAD00001005895 2
EGAD00001005896 2
EGAD00001005897 2
EGAD00001005898 2
EGAD00001005899 2
EGAD00001005900 2
EGAD00001005901 2
EGAD00001005902 2
EGAD00001005903 2
EGAD00001005904 2
EGAD00001005905 2
EGAD00001005906 2
EGAD00001005907 2
EGAD00001005908 2
EGAD00001005909 2
EGAD00001005910 2
EGAD00001005911 2
EGAD00001005912 2
EGAD00001005913 2
EGAD00001008012 2
EGAD00001008013 2
Publications Citations
Response to angiotensin blockade with irbesartan in a patient with metastatic colorectal cancer.
Ann Oncol 27: 2016 801-806
21
Molecular etiology of an indolent lymphoproliferative disorder determined by whole-genome sequencing.
Cold Spring Harb Mol Case Stud 2: 2016 a000679
1
Personalized oncogenomics in the management of gastrointestinal carcinomas-early experiences from a pilot study.
Curr Oncol 23: 2016 e571-e575
7
Genomic profiling of pelvic genital type leiomyosarcoma in a woman with a germline CHEK2:c.1100delC mutation and a concomitant diagnosis of metastatic invasive ductal breast carcinoma.
Cold Spring Harb Mol Case Stud 3: 2017 a001628
4
Carcinoma ex pleomorphic adenoma: case report and options for systemic therapy.
Curr Oncol 24: 2017 e251-e254
6
Detection and genomic characterization of a mammary-like adenocarcinoma.
Cold Spring Harb Mol Case Stud 3: 2017 a002170
8
Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing.
Cold Spring Harb Mol Case Stud 4: 2018 a002329
21
Molecular characterization of ERBB2-amplified colorectal cancer identifies potential mechanisms of resistance to targeted therapies: a report of two instructive cases.
Cold Spring Harb Mol Case Stud 4: 2018 a002535
12
Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making.
Cold Spring Harb Mol Case Stud 4: 2018 a002626
10
Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma.
NPJ Precis Oncol 2: 2018 8
7
Whole-genome and transcriptome profiling of a metastatic thyroid-like follicular renal cell carcinoma.
Cold Spring Harb Mol Case Stud 4: 2018 a003137
6
Clinical outcomes after whole-genome sequencing in patients with metastatic non-small-cell lung cancer.
Cold Spring Harb Mol Case Stud 5: 2019 a002659
1
Base excision repair deficiency signatures implicate germline and somatic MUTYH aberrations in pancreatic ductal adenocarcinoma and breast cancer oncogenesis.
Cold Spring Harb Mol Case Stud 5: 2019 a003681
24
Genomic characterization of a well-differentiated grade 3 pancreatic neuroendocrine tumor.
Cold Spring Harb Mol Case Stud 5: 2019 a003814
12
The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system.
Cold Spring Harb Mol Case Stud 5: 2019 a004143
2
Fluorouracil sensitivity in a head and neck squamous cell carcinoma with a somatic DPYD structural variant.
Cold Spring Harb Mol Case Stud 6: 2020 a004713
2
Temporal Dynamics of Genomic Alterations in a BRCA1 Germline-Mutated Pancreatic Cancer With Low Genomic Instability Burden but Exceptional Response to Fluorouracil, Oxaliplatin, Leucovorin, and Irinotecan.
JCO Precis Oncol 2: 2018 PO.18.00057
0
Tumor infiltrating neutrophils and gland formation predict overall survival and molecular subgroups in pancreatic ductal adenocarcinoma.
Cancer Med 10: 2021 1155-1165
9
Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy.
Cell Rep 37: 2021 110023
6
Clinical response to nivolumab in an INI1-deficient pediatric chordoma correlates with immunogenic recognition of brachyury.
NPJ Precis Oncol 5: 2021 103
16
A platform for oncogenomic reporting and interpretation.
Nat Commun 13: 2022 756
3
Whole-genome and transcriptome analysis of advanced adrenocortical cancer highlights multiple alterations affecting epigenome and DNA repair pathways.
Cold Spring Harb Mol Case Stud 8: 2022 a006148
4
TMBur: a distributable tumor mutation burden approach for whole genome sequencing.
BMC Med Genomics 15: 2022 190
2
Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma.
Nat Commun 13: 2022 5941
11
Characterization of the immune cell landscape in CRC: Clinical implications of tumour-infiltrating leukocytes in early- and late-stage CRC.
Front Immunol 13: 2022 978862
4
Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration.
NPJ Precis Oncol 7: 2023 31
3
Immune Activation following Irbesartan Treatment in a Colorectal Cancer Patient: A Case Study.
Int J Mol Sci 24: 2023 5869
0
ERα-associated translocations underlie oncogene amplifications in breast cancer.
Nature 618: 2023 1024-1032
16
Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers.
NPJ Precis Oncol 7: 2023 73
2
Exploration of Germline Correlates and Risk of Immune-Related Adverse Events in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors.
Curr Oncol 31: 2024 1865-1875
0
Whole genome and transcriptome integrated analyses guide clinical care of pediatric poor prognosis cancers.
Nat Commun 15: 2024 4165
0