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Preeclampsia InterPregGen Consortium: Large-scale GWAS meta-analysis of maternal preclampsia cases and controls from Europe and Central Asia. Plus extension of earlier European fetal preeclampsia GWAS meta-analysis (see EGAS00001001048) by adding Central Asian fetal preeclampsia cases and controls. Datasets provided under this study are GWAS meta-analysis summary statistics and individual level GWAS genotype data. Related InterPregGen Consortium data are also provided under studies EGAS00001000416 and EGAS00001000417 (whole genome sequence data for 100 unrelated Uzbeks and 100 unrelated Kazakhs) and EGAS00001001048 (European fetal preeclampsia GWAS summary statistics and genotype data

Preeclampsia (PE) is a syndrome affecting pregnant mothers and fetus/babies characterised by hypertension and proteinuria, and is a leading cause of maternal and fetal death and of premature births worldwide. The InterPregGen Consortium was funded by a European Framework 7 (FP7) grant and grew out of the WTCCC3 GWAS comparing ~2000 UK PE mothers with ~6000 common UK controls. The EGAS00001001266 study includes two components the FP7 InterPregGen project: (a) GWAS case-control meta-analysis of maternal PE cases from Europe (UK, Iceland, Norway, Denmark, Finland) and Central Asia (Kazakhstan, Uzbekistan); (b) GWAS case-control meta-analysis of PE fetal (baby) cases from Europe (UK, Iceland, Norway, Denmark) and Central Asia (Kazakhstan, Uzbekistan)

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010000854 Illumina Human670-QuadCustom_v1 3980
EGAD00010001917 Unknown HumanOmni25M-8v1-1 180
EGAD00010001918 Unknown HumanOmni2-5-8-v1-1-C 2658
EGAD00010001919 Unknown HumanOmni25-8v1-1 58
EGAD00010001945 llumina 2.5-8 3004
EGAD00010001947 OmniExpress 2305
EGAD00010001949 Infinium GSA 2321
EGAD00010001983 4
EGAD00010001984 12
EGAD00010001985 4
EGAD00010001986 10
EGAD00010001987 4
EGAD00010001988 4
Publications Citations
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.
Nat Commun 11: 2020 5976
The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice.
Immunity 54: 2021 1231-1244.e4
Genetic effects on the timing of parturition and links to fetal birth weight.
Nat Genet 55: 2023 559-567
Polygenic prediction of preeclampsia and gestational hypertension.
Nat Med 29: 2023 1540-1549