Study
Independent development of lymphoid and histiocytic malignancies from a shared early precursor
Study ID | Alternative Stable ID | Type |
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EGAS00001001353 | Other |
Study Description
Recent reports have described lineage flexibility in patients with recurrent hematologic malignancies. We encountered a boy with T-lineage acute lymphoblastic leukemia, non-Langerhans cell histiocytosis and histiocytic sarcoma. All tumors showed identical T-cell receptor rearrangements, but SNP arrays and whole exome sequencing revealed unique aberrations in each tumor. From the genetic data we conclude that the tumors were derived from a precursor cell with lineage plasticity for both lymphoid and myeloid development. From this precursor cell, the tumors evolved with independent genetic progression in a non-linear manner.
Study Datasets 1 dataset.
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Dataset ID | Description | Technology | Samples |
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EGAD00001001596 |
Whole Exome Sequencing data from the germline of the patient as well as the tumors in bone marrow (T-ALL), Liver (Histiocytic Sarcoma) and ileum (non-Langerhans Cell Histiocytosis).
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AB 5500xl Genetic Analyzer | 4 |
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