CD4+ T cell subsets stratified by complement receptor type 2 (CR2) expression
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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By differential gene expression analysis followed by protein expression and functional studies, we define that the naive T cells having divided the least since thymic emigration express complement receptors (CR1 and CR2) known to bind complement C3b- and C3d-decorated microbial products and, following activation, produce IL-8 (CXCL8), a major chemoattractant for neutrophils in bacterial defense. We also observed an IL-8–producing memory T cell subpopulation coexpressing CR1 and CR2 and with a ... (Show More)
|Illumina HiSeq 2500||24|