Dataset

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2

Dataset ID Technology Samples
EGAD00001003793 Illumina HiSeq 2500 24

Dataset Description

By differential gene expression analysis followed by protein expression and functional studies, we define that the naive T cells having divided the least since thymic emigration express complement receptors (CR1 and CR2) known to bind complement C3b- and C3d-decorated microbial products and, following activation, produce IL-8 (CXCL8), a major chemoattractant for neutrophils in bacterial defense. We also observed an IL-8–producing memory T cell subpopulation coexpressing CR1 and CR2 and with a gene expression signature resembling that of RTEs. JCI Insight. 2017;2(16):e93739. https://doi.org/10.1172/jci.insight.93739

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

JDRF/Wellcome Diabetes and Inflammation Laboratory Data Access Committee
Contact person: DIL Data Manager
Email: dil-data [at] well [dot] ox [dot] ac [dot] uk
More details: EGAC00001000756

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