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A new subgroup of hepatocellular adenomas with sonic hedgehog pathway activation

Hepatocellular adenomas (HCA) are benign liver tumors divided in molecular subtypes characterized by mutations inactivating HNF1A, activating β-catenin or the IL-6/JAK/STAT inflammatory pathway. Molecular analyses of 533 HCA developed in 411 patients identified a new tumor subgroup with Sonic Hedgehog pathway activation due to focal deletions creating INHBE promoter/GLI1 fusions.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001003092 Illumina HiSeq 2000 21
Publications Citations
Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
Gastroenterology 152: 2017 880-894.e6
131
Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis.
Nat Commun 8: 2017 1315
135