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A new subgroup of hepatocellular adenomas with sonic hedgehog pathway activation

Using sequencing and gene expression analyses, we identified a subgroup of HCA characterized by fusion of the INHBE and GLI1 genes and activation of sonic hedgehog pathway. Molecular subtypes of HCAs associated with different patients’ risk factors for HCA, disease progression, and pathology features of tumors. This classification system might be used to select treatment strategies for patients with HCA. Related Publication: Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation Nault, Jean-CharlesLaurent, Christophe et al. Gastroenterology , Volume 152 , Issue 4 , 880 - 894.e6

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FunGeST - Functional Genomics from cancer research to personalized medicine

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the Data Recipient has requested access. The Data Recipient agrees to be bound by these terms and conditions. Definitions GDPR: This DAA makes both parties compliant with the Regulation (EU) 2016/679 of the European Parliament and of the Council, that is, the General Data Protection Regulation (herein referred to as the ‘GDPR’). Data: Refers to managed controlled access datasets (the Data). Under this Agreement, the Data is pseudonymised. Data Access/Transfer: Refers to an Institution’s right to request access to the Data and retrieve them from the Data Controller’s Institution upon approval of this hDAA by the corresponding DAC within the Data Controller’s Institution. Data Handling: Refers to an Institution’s ability to analyse and manipulate the Data within its own computer network. Data Controller(s): Refers to an Institution, responsible for the generation of the Data and its pseudonymisation. A key-code permitting relinkage to Data Subjects is kept by the Data Controller(s). Data Subject: Refers to any individual who is the source of any Data covered by this Agreement. Data Recipient (‘You’): Refers to the Institution who requests Access to the Data through this Agreement. Authorised Personnel: The individual(s) at the Institution requesting Access to the Data. Research Project: The Project for which You have requested Access to the Data. Publications: Refers, without limitation, to any and all articles published in print journals, electronic journals, reviews, books, posters, and other written and verbal presentations of Research that have been accepted by peer review. FunGeST: This DAA was written for the FunGeST functional genomics projects headed at the CRC (Centre de recherche des Cordeliers, Paris, France) 1. You, the Data Recipient, agree to only use the Data for the Purpose of the Project, for Research Purposes only and not in any profit-making activities. You further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I; 2. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. You undertake not to use or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. Without prejudice to the generality of the foregoing, you agree to use at least the measures set out in Appendix I to protect these Data; 3. You agree not to attempt to identify Data Subjects; 4. You agree not to link or combine the Data to other information or archived data available in a way that could re-identify the Data Subjects, even if access to that data has been formally granted to you or is freely available without restriction. 5. You and your Authorised Personnel agree to take into consideration any usage restrictions (if any), stemming from consent, i.e. the appropriate lawful basis for processing the Data, as well as any usage restrictions stemming from any applicable internal policies of your Institution; 6. You agree that in handling this Data You will follow an up-to-date information technology (IT) policy that must include, at a minimum, the following items: a. Logging and auditing of Access to the Data and to the computer network; b. Password protection to computer network and/or strong data encryption; c. Virus and malware protection to computers on the computer network; d. Secure backup procedure; 7. You acknowledge that Access to the Data is granted for the duration of the Project described in Section I, and these restrictions are specific to that particular Project. Any utilization of the Data for a different Project will require prior approval through a new Agreement. 8. You recognize that nothing in this Agreement shall operate to transfer to You any intellectual property rights to the Data. 9. You agree not to make intellectual property claims on the Data and not to use intellectual property protection in ways that would prevent or block Access to, or use of, any element of the Data. 10. You can elect to perform further Research that would add intellectual and resource capital to the Data, and decide to obtain intellectual property rights on these downstream discoveries. In this case, You agree to implement licensing policies that will not obstruct further Research, following the Organisation for Economic Co-operation and Development Guidelines. 11. You agree that the Research Project 1) bears no legal responsibility for the accuracy or comprehensiveness of the Data; 2) accepts no liability for indirect, consequential, or incidental damages or losses arising from use of the Data; and 3) bears no responsibility for the further analysis or interpretation of these Data over and above that published by the Controller(s). 12. You agree to hold the Data Subject(s) and Data Controller(s) harmless and to defend and indemnify all these parties against all liabilities, demands, damages, expenses, and losses arising out of Your use for any Purpose of the Data. 13. You agree to a moratorium on publishing global analyses of the dataset until the Data Controller(s) have published their own global analysis or twelve (12) months, the maximum, have passed from the time the Data were deposited, whichever occurs first. You acknowledge that prompt publication or public disclosure of the results of the Research Project is encouraged. You also agree that by publishing Your global analyses of the Data, you will not disclose any results generated from the Data. 14. You agree to acknowledge the contribution of the Data Controller(s) in all oral and written presentations, disclosures, and Publications resulting from all analyses of the Data. 15. You agree to use the Data in Your laboratory. Any Authorised Personnel shall work under Your direct supervision. You agree to distribute a copy of these terms to the Authorised Personnel. 16. You may not transfer any information included in the Data to anyone unless specifically designated in the Research Project, or by prior specific or general written authorisation of the Data Controller(s) responsible for the generation of the original Data in each case. 17. You may not transfer the Data itself to anyone outside the Institution, unless the Controller(s) has (have) approved such transfer and its terms in writing. 18. Should You wish to share the Data with an external collaborator, the external collaborator must complete a separate Data Access Agreement. 19. You shall ensure that ‘all’ who have Access to the Data, namely You and Your Authorised Personnel, will be listed out, and are made aware and be bound by the terms of this Agreement. You remain solely and fully responsible for Your Authorised Personnel’s non-compliance with the provision of the Agreement and/or applicable laws. 20. In case of a breach of security resulting from ‘accidental’ use of Data by You and Your Authorised Personnel, which leads to disclosure of Data, then You must report this to Data Controller(s) within 72 hours maximum, and follow any relevant rule as provided by the GDPR. 21. In case of a ‘non-accidental or minor’ breach of DAA by You You will further be required to destroy any Data held. 22. You accept that this Agreement will terminate immediately upon ‘any’ breach by You, or its termination (see Section I). 23. You endeavour to settle any dispute with the Data Controller(s) amicably. If you are unable to reach an Agreement, you will meet and negotiate in good faith in an effort to resolve the issue. If the issue has not been resolved within a reasonable period (e.g. 30 calendar days), you are both entitled to submit it for resolution by an arbitrator. 24. Further, the language of the proceedings will be ‘English’ if not otherwise agreed. The award of the arbitration will be final and binding upon the parties concerned. 25. This Agreement (and any dispute, controversy, proceedings, or claim of whatever nature arising out of it or its formation) shall be interpreted, governed by and construed in accordance with the Laws of France, and shall be subject to the exclusive jurisdiction of the French Courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001002091 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00001415462 bam 5.6 GB
EGAF00001415463 bam 6.1 GB
EGAF00001415464 bam 8.6 GB
EGAF00001415465 bam 10.4 GB
EGAF00001415466 bam 9.8 GB
EGAF00001415467 bam 8.6 GB
EGAF00001415468 bam 9.5 GB
EGAF00001415469 bam 9.8 GB
EGAF00001415470 bam 9.7 GB
EGAF00001415471 bam 7.7 GB
EGAF00001415472 bam 8.1 GB
EGAF00001415473 bam 9.5 GB
EGAF00001415474 bam 8.6 GB
EGAF00001415475 bam 7.6 GB
EGAF00001415476 bam 8.7 GB
EGAF00001415477 bam 8.5 GB
EGAF00001415478 bam 8.5 GB
EGAF00001415479 bam 9.5 GB
EGAF00001415480 bam 9.3 GB
EGAF00001415481 bam 9.5 GB
EGAF00001415482 bam 9.8 GB
EGAF00001415483 bam 3.5 GB
EGAF00001415484 bam 6.9 GB
EGAF00001415485 bam 7.3 GB
EGAF00001415486 bam 7.7 GB
EGAF00001415487 bam 6.9 GB
EGAF00001415488 bam 6.4 GB
EGAF00001415489 bam 5.1 GB
EGAF00001415490 bam 3.7 GB
EGAF00001415491 bam 6.5 GB
EGAF00001415492 bam 6.0 GB
EGAF00001415493 bam 6.7 GB
EGAF00001415494 bam 74.6 GB
EGAF00001415495 bam 110.9 GB
EGAF00001415496 bam 80.1 GB
EGAF00001415497 bam 67.0 GB
EGAF00001415498 bam 66.2 GB
EGAF00001415499 bam 115.0 GB
38 Files (763.9 GB)