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Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas

Intratumor heterogeneity and divergent clonal lineages within and among primary and recurrent hepatocellular carcinomas (HCCs) produce challenges to patient management. We investigated genetic and epigenetic variations within liver tumors, among hepatic lesions, and between primary and relapsing tumors. We performed whole-genome, whole-exome, or targeted capture sequencing analyses HCC specimens collected from multiple tumor regions and matched initial and recurrent tumors to obtain a systematic evaluation of intra- and intertumor genetic heterogeneity in HCC samples and to identify genetic changes associated with tumor progression and recurrence.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001005450 Illumina HiSeq 2000 255
EGAD00001005451 Illumina HiSeq 2000 24
EGAD00001005452 Illumina HiSeq 2000 12
EGAD00001005453 Illumina HiSeq 2000 86