Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas

Study ID	Alternative Stable ID	Type
EGAS00001002094		Other

Study ID

Alternative Stable ID

Type

EGAS00001002094

Other

Study Description

Intratumor heterogeneity and divergent clonal lineages within and among primary and recurrent hepatocellular carcinomas (HCCs) produce challenges to patient management. We investigated genetic and epigenetic variations within liver tumors, among hepatic lesions, and between primary and relapsing tumors. We performed whole-genome, whole-exome, or targeted capture sequencing analyses HCC specimens collected from multiple tumor regions and matched initial and recurrent tumors to obtain a systematic evaluation of intra- and intertumor genetic heterogeneity in HCC samples and to identify genetic changes associated with tumor progression and recurrence.

Dataset ID	Description	Technology	Samples
EGAD00001005450	This dataset contains target capture sequence data from 255 samples, including 154 tumors and 101 normal samples. All the experiments were performed on Illumina HiSeq 2000 platform with raw reads stored in fastq format. This dataset contains target capture sequence data from 255 samples, including 154 tumors and 101 normal samples. All the experiments were performed on Illumina HiSeq 2000 platform with raw reads stored in fastq format.	Illumina HiSeq 2000	255
EGAD00001005451	This dataset contains whole genome sequence data from 24 samples, including 16 tumors and 8 normal samples. All the experiments were performed on Illumina HiSeq 2000 platform with raw reads stored in fastq format. This dataset contains whole genome sequence data from 24 samples, including 16 tumors and 8 normal samples. All the experiments were performed on Illumina HiSeq 2000 platform with raw reads stored in fastq format.	Illumina HiSeq 2000	24
EGAD00001005452	This dataset contains whole genome sequence data from 12 samples from 1 patient, including 8 tumor sectors and 4 normal samples. All the experiments were performed on Illumina HiSeq platform with raw reads stored in fastq format. This dataset contains whole genome sequence data from 12 samples from 1 patient, including 8 tumor sectors and 4 normal samples. All the experiments were performed on Illumina HiSeq platform with raw reads stored in fastq format.	Illumina HiSeq 2000	12
EGAD00001005453	This dataset contains whole exome sequence data from 86 samples from 6 patient. All the experiments were performed on Illumina HiSeq platform with raw reads stored in fastq format. This dataset contains whole exome sequence data from 86 samples from 6 patient. All the experiments were performed on Illumina HiSeq platform with raw reads stored in fastq format.	Illumina HiSeq 2000	86

Dataset ID

Description

Technology

Samples

EGAD00001005450

This dataset contains target capture sequence data from 255 samples, including 154 tumors and 101 normal samples. All the experiments were performed on Illumina HiSeq 2000 platform with raw reads stored in fastq format.

Illumina HiSeq 2000

255

EGAD00001005451

This dataset contains whole genome sequence data from 24 samples, including 16 tumors and 8 normal samples. All the experiments were performed on Illumina HiSeq 2000 platform with raw reads stored in fastq format.

Illumina HiSeq 2000

EGAD00001005452

This dataset contains whole genome sequence data from 12 samples from 1 patient, including 8 tumor sectors and 4 normal samples. All the experiments were performed on Illumina HiSeq platform with raw reads stored in fastq format.

Illumina HiSeq 2000

EGAD00001005453

This dataset contains whole exome sequence data from 86 samples from 6 patient. All the experiments were performed on Illumina HiSeq platform with raw reads stored in fastq format.

Illumina HiSeq 2000

Study

Study Description

Study Datasets 4 datasets.

Who archives the data?

The European Genome-phenome Archive (EGA) is part of the ELIXIR infrastructure.