Identification of synthetic lethal genes by CRISPR Cas9 library
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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Genetic redundancy has evolved as a way for human cells to survive the loss of genes that are single copy and essential in other organisms, but also allows tumours to survive despite having highly rearranged genomes. In this study we CRISPR screen 1,191 gene pairs, including paralogues and known and predicted synthetic lethal interactions to identify 105 gene combinations whose co-disruption results in a loss of cellular fitness. 27 pairs influence fitness across multiple cell lines including ... (Show More)
|Illumina HiSeq 2500||27|