Preclinical evolution of haematological malignancies
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
The incidence of acute myeloid leukemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 60. Only 10-15% of cases evolve from a pre-existing myeloproliferative or myelodysplastic disorder; the remaining cases arise de novo without a detectable prodrome and are diagnosed upon development of bone marrow failure. Analysis of diagnostic blood samples has demonstrated that de novo AML is preceded by the accumulation of somatic mutations in pre-leukemic hematopoietic ... (Show More)
|Illumina HiSeq 2000,Illumina HiSeq 2500||628|