Preclinical evolution of haematological malignancies

Study ID Alternative Stable ID Type
EGAS00001002128 Cancer Genomics

Study Description

This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
The incidence of acute myeloid leukemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 60. Only 10-15% of cases evolve from a pre-existing myeloproliferative or myelodysplastic disorder; the remaining cases arise de novo without a detectable prodrome and are diagnosed upon development of bone marrow failure. Analysis of diagnostic blood samples has demonstrated that de novo AML is preceded by the accumulation of somatic mutations in pre-leukemic hematopoietic ... (Show More)
Illumina HiSeq 2000,Illumina HiSeq 2500 628

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