Study
The Genetic Landscape of BCL2 Break Negative Follicular Lymphoma
Study ID | Alternative Stable ID | Type |
---|---|---|
EGAS00001002164 | Other |
Study Description
Background: 15% of high and 50% of low stage FL lack the t(14;18). Nevertheless, most of these cases express BCL2 by so far unknown mechanisms. Principals/Methodology: To find molecular mechanisms, triggering FL-pathogenesis in t(14;18)-negative FL, the exonic SNV-profiles of 33 FL with and 16 FL without t(14;18) were assessed by whole exome-sequencing and external SNV-data integration. The SNV-profile of the whole exome-sequenced FL was correlated with copy number, LOH and gene-expression data. Finally, the N-glycosylation status was assessed (LympTrack assay) in a separate validation cohort. Results: SNVs in FL with and without t(14;18) affected different genes, but accumulated in similar pathways, e.g. apoptosis, epigenetic processes and cell cycle/proliferation. Mutations in genes associated with immune-response were more prominently and those associated with NFkB and N-glycosylation selectively enriched in t(14;18)-negative FL. ~50% of mutated genes showed BCL2-asociation at high confidence in FL with and without t(14;18). Moreover, among the genes mutated in t(14;18)-negative ... (Show More)
Study Datasets 11 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001003509 |
Whole Exome Sequencing reads consisting of BAM paired end reads from Follicular Lymphoma samples.
|
11 | |
EGAD00010001232 |
CN/LOH-profile of Translocation-negative FL_8
|
Affymetrix SNP 6.0 | 1 |
EGAD00010001233 |
CN/LOH-profile of Translocation-negative FL_5
|
Affymetrix SNP 6.0 | 1 |
EGAD00010001234 |
CN/LOH-profile of Translocation-negative FL_9
|
Affymetrix SNP 6.0 | 1 |
EGAD00010001235 |
CN/LOH-profile of Translocation-negative FL_11
|
Affymetrix SNP 6.0 | 1 |
EGAD00010001236 |
CN/LOH-profile of Translocation-negative FL_4
|
Affymetrix SNP 6.0 | 1 |
EGAD00010001237 |
CN/LOH-profile of Translocation-negative FL_10
|
Affymetrix SNP 6.0 | 1 |
EGAD00010001238 |
CN/LOH-profile of Translocation-negative FL_2
|
Affymetrix SNP 6.0 | 1 |
EGAD00010001239 |
CN/LOH-profile of Translocation-negative FL_6
|
Affymetrix SNP 6.0 | 1 |
EGAD00010001240 |
CN/LOH-profile of Translocation-negative FL_1
|
Affymetrix SNP 6.0 | 1 |
EGAD00010001241 |
CN/LOH-profile of Translocation-negative FL_7
|
Affymetrix SNP 6.0 | 1 |
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