Study

The Genetic Landscape of BCL2 Break Negative Follicular Lymphoma

Study ID Alternative Stable ID Type
EGAS00001002164 Other

Study Description

Background: 15% of high and 50% of low stage FL lack the t(14;18). Nevertheless, most of these cases express BCL2 by so far unknown mechanisms. Principals/Methodology: To find molecular mechanisms, triggering FL-pathogenesis in t(14;18)-negative FL, the exonic SNV-profiles of 33 FL with and 16 FL without t(14;18) were assessed by whole exome-sequencing and external SNV-data integration. The SNV-profile of the whole exome-sequenced FL was correlated with copy number, LOH and gene-expression data. Finally, the N-glycosylation status was assessed (LympTrack assay) in a separate validation cohort. Results: SNVs in FL with and without t(14;18) affected different genes, but accumulated in similar pathways, e.g. apoptosis, epigenetic processes and cell cycle/proliferation. Mutations in genes associated with immune-response were more prominently and those associated with NFkB and N-glycosylation selectively enriched in t(14;18)-negative FL. ~50% of mutated genes showed BCL2-asociation at high confidence in FL with and without t(14;18). Moreover, among the genes mutated in t(14;18)-negative ... (Show More)

Study Datasets 11 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001003509
Whole Exome Sequencing reads consisting of BAM paired end reads from Follicular Lymphoma samples.
11
EGAD00010001232
CN/LOH-profile of Translocation-negative FL_8
Affymetrix SNP 6.0 1
EGAD00010001233
CN/LOH-profile of Translocation-negative FL_5
Affymetrix SNP 6.0 1
EGAD00010001234
CN/LOH-profile of Translocation-negative FL_9
Affymetrix SNP 6.0 1
EGAD00010001235
CN/LOH-profile of Translocation-negative FL_11
Affymetrix SNP 6.0 1
EGAD00010001236
CN/LOH-profile of Translocation-negative FL_4
Affymetrix SNP 6.0 1
EGAD00010001237
CN/LOH-profile of Translocation-negative FL_10
Affymetrix SNP 6.0 1
EGAD00010001238
CN/LOH-profile of Translocation-negative FL_2
Affymetrix SNP 6.0 1
EGAD00010001239
CN/LOH-profile of Translocation-negative FL_6
Affymetrix SNP 6.0 1
EGAD00010001240
CN/LOH-profile of Translocation-negative FL_1
Affymetrix SNP 6.0 1
EGAD00010001241
CN/LOH-profile of Translocation-negative FL_7
Affymetrix SNP 6.0 1

Who archives the data?

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