Orphan Tumour Study familial neuroblastoma
|Study ID||Alternative Stable ID||Type|
Study Datasets 5 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
The genetic basis of many rare childhood cancers remains unknown. These include a spectrum of infant soft tissue tumors without canonical gene fusions, encompassing congenital mesoblastic nephroma (CMN) of the kidney and infantile fibrosarcoma (IFS). Here, we integrated whole genome and transcriptome sequencing and identified diagnostic markers and novel therapeutic strategies.
|HiSeq X Ten||37|
We investigated the somatic genetic basis of Wilms’ tumour and found complex phylogenetic relations between tumours.
|HiSeq X Ten||203|
The aim of this study is to reconstruct the phylogenetic development of childhood tumours
|HiSeq X Ten||8|
Leukaemia and related blood cancers occur due to genetic changes that typically accumulate over many years. This study will employ targeted next-generation sequencing to retrace the preclinical evolution of several types of haematological malignancy. Investigating the progression of the earliest pre-malignant ancestral clones promises to offer valuable insights into early leukaemia evolution and therapeutic vulnerabilities of leukaemia stem cells.
|HiSeq X Ten,Illumina NovaSeq 6000||N/A|
We have performed single cell RNA-sequencing for infant and childhood B-cell acute lymphoblastic leukemias as well as infant acute myeloid leukemias at diagnosis. The sequencing was performed with 10X Chromium single cell 3’ and 5’ chemistry.
|HiSeq X Ten||3|