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Single-cell profiling maps the spectrum of crosstalk between glioma cells and tumor associated macrophages

Tumor associated macrophages (TAMs) are a heterogeneous glioma infiltrate, implicated in cancer progression. We performed single-cell RNA-sequencing, to survey TAM response-patterns in glioma.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001003107 Illumina HiSeq 2500 1
EGAD00001003108 Illumina HiSeq 2500 1
EGAD00001003109 Illumina HiSeq 2500 1
EGAD00001003110 Illumina HiSeq 2500 1
EGAD00001003111 Illumina HiSeq 2500 1
EGAD00001003112 Illumina HiSeq 2500 1
EGAD00001003113 Illumina HiSeq 2500 1
EGAD00001003114 Illumina HiSeq 2500 1
Publications Citations
Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment.
Genome Biol 18: 2017 234
CONICS integrates scRNA-seq with DNA sequencing to map gene expression to tumor sub-clones.
Bioinformatics 34: 2018 3217-3219
The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation.
Cancer Discov 9: 2019 1708-1719
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states.
Nat Genet 53: 2021 1469-1479
Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow-Derived Macrophages.
Cancer Res 83: 2023 771-785
Glioblastoma heterogeneity at single cell resolution.
Oncogene 42: 2023 2155-2165
Dissecting the tumor microenvironment of epigenetically driven gliomas: Opportunities for single-cell and spatial multiomics.
Neurooncol Adv 5: 2023 vdad101
Single-cell characterization of human GBM reveals regional differences in tumor-infiltrating leukocyte activation.
Elife 12: 2023 RP92678