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Hip OA Functional Genomics

The aim of this work is to apply an integrated systems approach to understand the biological underpinnings of hip osteoarthritis that culminates in the need for total joint replacement (TJR). This study is a feasibility pilot that integrates functional genomics data from diseased and non-diseased tissues of OA patients who have undergone TJR. For each tissue, we characterised epigenetic marks (methylation), gene transcription (RNASeq) and expression (quantitative proteomics). We also generated genotype data on the HumanCoreExome array for each individual.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001003354 Illumina HiSeq 2500 27
EGAD00010001291 Illumina HumanMethylation450K 27
EGAD00010001292 Illumina InfiniumCoreExome-24v1-1_A 9
Publications Citations
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.
Nat Genet 50: 2018 549-558
154
Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis.
Rheumatology (Oxford) 57: 2018 1481-1489
10
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
Nat Genet 51: 2019 230-236
247
Accelerating functional gene discovery in osteoarthritis.
Nat Commun 12: 2021 467
26
A molecular quantitative trait locus map for osteoarthritis.
Nat Commun 12: 2021 1309
39
Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis.
Ann Rheum Dis 80: 2021 1070-1074
22
A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis.
Hum Mol Genet 31: 2022 2090-2105
11