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Plasma pQTLs in INTERVAL cohort

Human pQTLs using UK INTERVAL (Cambridge CEU) plasma samples. pQTL mapping of 3,283 protein analytes assayed using SomaLogic SOMAscan, across 10.6M imputed genetic variants, in 3,301 samples.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001004080 3301
EGAD00010001544 Affymetrix Axiom UK Biobank + imputation to 1000GP3 and UK10K 3301
Publications Citations
Genomic atlas of the human plasma proteome.
Nature 558: 2018 73-79
691
Undulating changes in human plasma proteome profiles across the lifespan.
Nat Med 25: 2019 1843-1850
278
Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging.
Aging Cell 19: 2020 e13256
30
Robust Huber-LASSO for improved prediction of protein, metabolite and gene expression levels relying on individual genotype data.
Brief Bioinform 22: 2021 bbaa230
3
Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19.
Hum Genet 140: 2021 969-979
25
CoffeeProt: an online tool for correlation and functional enrichment of systems genetics data.
Nucleic Acids Res 49: 2021 W104-W113
3
Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases.
Nat Metab 3: 2021 1476-1483
31
A large-scale genetic correlation scan between rheumatoid arthritis and human plasma protein.
Bone Joint Res 11: 2022 134-142
4
Protein prediction for trait mapping in diverse populations.
PLoS One 17: 2022 e0264341
9
SVEP1 is an endogenous ligand for the orphan receptor PEAR1.
Nat Commun 14: 2023 850
5
Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.
Sci Adv 9: 2023 eadd4984
1