Multi-omics data of 1000 Inflammatory Bowel Disease patients

Study ID Alternative Stable ID Type
EGAS00001002702 Other

Study Description

Portal available at Inflammatory bowel disease (IBD) is a chronic complex disease of the gastrointestinal (GI) tract. Patients with IBD can experience a wide range of symptoms, but the pathophysiological mechanisms that cause these individual differences in clinical presentation remain largely unknown. In consequence, IBD is currently classified into subtypes using clinical characteristics. If we are to develop a more targeted treatment approach, molecular subtypes of IBD need to be discovered that can be used as new drug targets. To achieve this, we need multiple layers of molecular data are generated from the same IBD patients.We initiated the 1000IBD project to prospectively follow more than 1000 IBD patients from the Northern provinces of the Netherlands. For these patients, we have collected a uniquely large number of phenotypes and generated multi-omics profiles. To date, 1,215 participants have been enrolled in the project and enrolment is on-going, with 609 patients being present in the first data release. Phenotype data collected for these participants ... (Show More)

Study Datasets 5 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
Sequencing of V4 hypervariable region of 16S gene of microbiota present in feces of IBD patients
Sequencing of V4 hypervariable region of 16S gene from microbiota present in intestinal biopsies of IBD patients
Complete Microbiome Metagenomics from feces of 355 IBD patients; The sequencer used was the Illumina HiSeq 2000 with a paired end reads design, reflected in the 2 FastQ format files per sample.
Illumina HiSeq 2000 355
Intensity files for Immunochip genotypes from blood
Illumina Immunochip 314
This set features unfiltered, aligned, UMI-based single cell RNA sequencing count data for 5290 Blood, intraepithelial ileum (IEL) and lamina propria ileum (LPL) T cells from Crohn’s disease patients as published in Uniken Venema et al, Gastroenterology 2019
Smartseq2_adapted 3

Who archives the data?