Pre clinical evolution of haematological malignancies

Study ID Alternative Stable ID Type
EGAS00001002964 Cancer Genomics

Study Description

Deep targeted sequencing of 291 peripheral blood samples taken 1-20 years prior diagnosis of a haematological malignancy alongside age- and sex-matched controls. Key objective is to distinguish indolent age-related clonal haematopoiesis from pre-cancer and to derive predictive models for early risk-stratification.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Leukaemia and related blood cancers occur due to genetic changes that typically accumulate over many years. This study will employ targeted next-generation sequencing to retrace the preclinical evolution of several types of haematological malignancy. Investigating the progression of the earliest pre-malignant ancestral clones promises to offer valuable insights into early leukaemia evolution and therapeutic vulnerabilities of leukaemia stem cells.
Illumina HiSeq 2500,Illumina HiSeq 4000 48

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