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Characterizing the immune and genome landscapes for osteosarcoma

Osteosarcoma have heavily rearranged genomes and moderate tumor mutation burden, which suggests that the patients may express neoantigens that could be targeted by immune cells. To characterize the immunogenomic landscape of this disease, we performed genome, transcriptome, immune and proteomic profiling of 48 patients comprised largely of relapsed and metastatic cases from both pediatric and adult patients.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001008435 Illumina HiSeq 2000 1
EGAD00001008436 Illumina HiSeq 2000 86
Publications Citations
Immuno-genomic landscape of osteosarcoma.
Nat Commun 11: 2020 1008
104
The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma.
Nat Commun 13: 2022 3057
7