Finding structural variation from the patient-derived xenografts of pediatric T-cell leukemia at the single-cell level
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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In this study, we aimed to identify somatic structural variation of T-cell acute lymphoblastic leukemias (T-ALLs_ from patient-derived xenografts (PDX) at the single-cell level. For this purpose, we performed strand-specific single-cell sequencing of PDX-derived T-ALL relapse samples from two juvenile patients (P1, P33). To validate structural variation detected via scTRIP, we profiled whole exome sequencing (WES) data from P33 (samples taken during initial disease, remission, relapse), and ... (Show More)
|Illumina HiSeq 2000,NextSeq 500||124|