Dataset

Finding structural variation from the patient-derived xenografts of pediatric T-cell leukemia at the single-cell level

Dataset ID Technology Samples
EGAD00001004499 Illumina HiSeq 2000,NextSeq 500 124

Dataset Description

In this study, we aimed to identify somatic structural variation of T-cell acute lymphoblastic leukemias (T-ALLs_ from patient-derived xenografts (PDX) at the single-cell level. For this purpose, we performed strand-specific single-cell sequencing of PDX-derived T-ALL relapse samples from two juvenile patients (P1, P33). To validate structural variation detected via scTRIP, we profiled whole exome sequencing (WES) data from P33 (samples taken during initial disease, remission, relapse), and mate-pair sequencing data from P1 (relapse).

Who controls access to this dataset

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact:

EMBL genome biology research group for structural variation (Strand-seq application)
Contact person: Jan Korbel
Email: korbel [at] embl [dot] de
More details: EGAC00001001091

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