Genome Wide Association Study:GR@ACE Stage I

The Genome Research program at Fundacio ACE (GR@ACE, Barcelona, Spain), represents a new effort to study Alzheimer's Disease susceptibility. The GR@ACE study comprises 7,409 unrelated individuals. 4,120 AD cases were diagnosed at Fundació ACE Memory Clinic (Barcelona, Spain). 3,289 Controls were obtained from three collections (Fundació ACE, Barcelona; DNA National Biobank, Salamanca and HU Valme, Seville). Genotyping was carried out using the 815K Axiom Spain Biobank array (Affymetrix.) in the Spanish national center for genotyping (CEGEN, Santiago de Compostela, Spain). After genotyping, an extensive quality control was conducted, including re-sampling, gender match, stratification, relatedness, heterozygosity, differential missingness and HWD analyses.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

3 Datasets 3 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00010001653	Binary Plink files for post-GWAS quality control in 7409 samples genotyped using Axiom 815K Spanish Biobank array (Thermo Fisher)	Axiom 815K Spanish Biobank array	7409
EGAD00010001654	Binary Plink files for pre-GWAS quality control in 7409 samples genotyped using Axiom 815K Spanish Biobank array (Thermo Fisher)	Axiom 815K Spanish Biobank array	7409
EGAD00010001655	Intensity calculation on the pixel values of the DAT file for 7409 samples genotyped using Axiom 815K Spanish Biobank array (Thermo Fisher)	Axiom 815K Spanish Biobank array	7409

Publications	Citations
The <i>MAPT</i> H1 Haplotype Is a Risk Factor for Alzheimer's Disease in <i>APOE</i> ε4 Non-carriers. Sánchez-Juan P, Moreno S, de Rojas I, Hernández I, Valero S, Alegret M, Montrreal L, García González P, Lage C, López-García S, Rodrííguez-Rodríguez E, Orellana A, Tárraga L, Boada M, Ruiz A. Front Aging Neurosci 11: 2019 327	18
Long runs of homozygosity are associated with Alzheimer's disease. Moreno-Grau S, Fernández MV, de Rojas I, Garcia-González P, Hernández I, Farias F, Budde JP, Quintela I, Madrid L, González-Pérez A, Montrreal L, Alarcón-Martín E, Alegret M, Maroñas O, Pineda JA, Macías J, GR@ACE study group, DEGESCO consortium, Marquié M, Valero S, Benaque A, Clarimón J, Bullido MJ, García-Ribas G, Pástor P, Sánchez-Juan P, Álvarez V, Piñol-Ripoll G, García-Alberca JM, Royo JL, Franco-Macías E, Mir P, Calero M, Medina M, Rábano A, Ávila J, Antúnez C, Real LM, Orellana A, Carracedo Á, Sáez ME, Tárraga L, Boada M, Cruchaga C, Ruiz A, Alzheimer’s Disease Neuroimaging Initiative. Transl Psychiatry 11: 2021 142	4
What does heritability of Alzheimer's disease represent? Baker E, Leonenko G, Schmidt KM, Hill M, Myers AJ, Shoai M, de Rojas I, Tesi N, Holstege H, van der Flier WM, Pijnenburg YAL, Ruiz A, Hardy J, van der Lee S, Escott-Price V. PLoS One 18: 2023 e0281440	7