TRACERx 100: RRBS data from a subset of the first 100 TRACERx tumours

TRACERx (TRAcking Cancer Evolution through therapy (Rx)) is a prospective cohort study designed to investigate intratumor heterogeneity (ITH) in relation to clinical outcome, and to determine the clonal nature of driver events and evolutionary processes in early stage non-small cell lung cancer (NSCLC). This study looks at multi-region RRBS data from the TRACERx100 cohort selected for quantity of material available and high tumour purity. RRBS data was collected for 122 tumour regions across 36 patients each with matched normal. A subset of this cohort was used in a sister study looking at tumour neo-antigen promoter methylation status in NSCLC (71 tumour regions across 28 patients for a total of 99 samples).

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001004798	TRACERx 100: RRBS data from a subset of the first 100 TRACERx tumours	Illumina HiSeq 2500	98

Publications	Citations
Understanding the impact of immune-mediated selection on lung cancer evolution. Rosenthal R, Swanton C, McGranahan N. Br J Cancer 124: 2021 1615-1617	3