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TRACERx 100: RRBS data from a subset of the first 100 TRACERx tumours

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TRACERx Academic Research Data Access Agreement for Sequence Data

Academic Research Access Agreement Sequencing Data BETWEEN: (1) FRANCIS CRICK INSTITUTE a registered charity in England and Wales no. 1140062 and a company registered in England and Wales no. 06885462, with its registered office at 1 Midland Road, London NW1 1AT (the ‘Crick’); and (2) [INSERT INSTITUTION DETAILS] (the “Recipient”). BACKGROUND The Recipient has requested access to the Data to conduct Research. Crick wishes to make the Data available to the Recipient for that purpose on the following terms and conditions. AGREED AS FOLLOWS 1. DEFINITIONS 1.1. The following definitions apply in this agreement. “Authorised User” means: (a) a Researcher employed by the Recipient; or (b) another researcher employed by the Recipient who has authored a relevant peer-reviewed article that Crick can locate on PubMed and who is working in the Research field; or (c) a student studying at the Recipient and is conducting Research under the direct supervision of a Researcher; or (d) a new researcher employed by the Recipient and is conducting Research under the direct supervision of a Researcher: in each case that is bound by confidentiality and non-use obligations in respect of Data set out in this Agreement, and “Authorised Users” shall mean each Authorised User based at the Recipient; “Data” means all and any human genetic sequencing data obtained from the Source Project that Crick elects to make available to the Recipient. Data does not include samples or biological materials, among other things; “Data Subject” means the person (irrespective of state of health) to whom Data refers and who has been informed of the purpose for which the Data is held and has given his/her informed consent thereto; “Intellectual Property” means (i) patents, designs, trade marks and trade names (whether registered or unregistered), copyright and related rights, database rights, know-how and confidential information; (ii) all other intellectual property rights and similar or equivalent rights anywhere in the world which currently exist or are recognised in the future; and (iii) applications, extensions and renewals in relation to any such rights; “PI” means Professor Charles Swanton of The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK; “Research” means the research project described in the Schedule, the principal purpose of which is to advance the understanding and treatment of cancer; “Researcher” means an individual who has: (a) authored a relevant peer-reviewed article that Crick can locate on PubMed and who is working in the Research field; and (b) has signed the form set out in the Schedule and has received acknowledgement from Crick of its acceptance; and “Source Project” means the TRAcking small-cell lung Cancer Evolution through theRapy (TRACERx) study, comprising the sequencing of multi-region lung cancer samples undertaken at The Francis Crick Institute, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK, to identify genetic sequence variants and mutations relevant to the development of human cancers. 1.1. The words “including”, “include”, “for example”, “in particular” and words of a similar effect shall not limit the general effect of the words which precede them. 1.2. References to persons shall be construed to include natural persons, bodies corporate, unincorporated associations and partnerships (whether or not any of them have separate legal personality). 1.3. Headings are all for reference only and shall be ignored when construing this Agreement. 2. PURPOSE 2.1. The Recipient may use Data for academic Research only, and shall not use the Data for any other purpose. 3. ACCESS 3.1. The Recipient shall only give access to any Data, or any identifiable material derived from the Data, to Authorised Users that are properly and directly supervised by one or more Researcher. 3.2. The Recipient shall not (and shall procure that no Authorised User shall): (a) copy, duplicate or sell the Data, or any part of it, on any medium; or (b) make the data (or any part of it) available to third parties other than as expressly permitted in Clause 4.2(a) and 9, in each case, without the prior written permission of Crick. The Recipient shall obtain Crick’s consent on a case-by-case basis. 3.3. On written notice, Crick may inspect and review the data security and management processes, and related documentation, relied upon by the Recipient. The Recipient shall provide (and shall ensure that its data storage providers provide) Crick with any access rights needed for Crick to carry out that inspection. Unless Crick identifies any deficiencies in the Recipient’s data security and management processes, Crick may not carry out more than one (1) inspection in each calendar year. 4. CONFIDENTIALITY 4.1. The Recipient acknowledges that the Data is the confidentiality information of Crick. The Recipient shall keep the Data confidential, and shall use all reasonable precautions to do so. Such precautions shall be no less onerous than those that the Recipient applies in respect of its own confidential information. 4.2. The Recipient shall not (and shall procure that no Authorised User shall) communicate or disclose any part of the Data to any person other than: (a) to those expressly permitted under Clause 3.1, which shall in each case be on a need to know basis only and subject to them agreeing to be bound by confidentiality and non-use terms no less onerous than those in this Agreement; or (b) if ordered to do so by a court of competent jurisdiction if there is a statutory obligation to do so, in which case the Recipient shall inform Crick in writing as soon as the Recipient is able to do so once such disclosure is sought. 5. DATA PROTECTION 5.1. The Recipient shall (and shall procure that each Authorised User shall) comply with all duties and obligations (including, among others, those relating to the storage, processing and use of Data, and to any Data Subject) arising under the Data Protection Act 1998, as amended from time to time, or equivalent provisions under EU or local national legislation no less onerous then those contained in the Data Protection Act. 5.2. The Recipient shall not, and shall procure that the Authorised Users shall not, analyse or make any use of any Data in any manner that has the potential to identify, or compromise the anonymity of, any Data Subject. 6. MAINTENANCE 6.1. If the Recipient becomes aware of, or suspects, any errors in the Data, it shall immediately notify Crick and provide details of the errors. 7. DATA REISSUE 7.1. The Recipient acknowledges that Data may be reissued from time to time and without notice. Upon becoming aware that the Data has been reissued for any reason (which may include at the request of sample donors and/or as the result of other ethical scrutiny), the Recipient shall immediately destroy all earlier versions of the Data. 8. INTELLECTUAL PROPERTY 8.1. Nothing in this Agreement shall transfer to the Recipient or any Authorised User any intellectual property rights in or relating to the Data. No rights under such intellectual property rights are granted or implied by this agreement other than the use right expressly granted in Clause 2.1. 9. PUBLICATIONS 9.1. The Recipient and any Authorised User may only publish Data if: (a) the publication comprises only parts of the Data, and not all of the Data; (b) it is not possible to identify the identity of any Data Subject from, or using, the Data contained in the publication; (c) Crick is provided with a copy of the publication at least thirty (30) days in advance of its proposed dissemination and, at Crick’s request and direction during that thirty (30) day review period, the Recipient: (i) delays the proposed dissemination for up to a further six (6) months; (ii) removes from the publication any Data specified by Crick; and (iii) removes any other information or data specified by Crick that Crick has provided to the Recipient in connection with the Research or under this agreement; and (d) the publication complies with Clause 9.2. 9.2. The Recipient shall ensure that each work based in whole or part on the Data that is authored by an Authorised User acknowledges the published paper from which the Data derives, the version of the Data, and the role of the Source Project and its funders in its distribution in accordance with customary scientific and academic practice. 9.3. Further, within any permitted publication including these data the CRUK Lung cancer TRACERx Consortium, the UCL Cancer Institute and The Francis Crick Institute shall be acknowledged in a manner consistent with the usual conventions in the field of research involved. 10. TERMINATION 10.1. This agreement will expire upon the earlier of: (a) completion of the Research; and (b) the first (1st) anniversary of Crick acknowledging receipt of the completed registration form in respect of the Research. 10.2. This agreement will terminate immediately upon any breach of any of its provisions by the Recipient or by any of the Authorised Users. 10.3. Either party may terminate this Agreement with immediate effect on written notice to the other. 10.4. Upon expiry or termination of this Agreement for any reason, the Recipient shall destroy all Data in its possession and in the possession of any Authorised User. 10.5. Expiry and termination of this agreement for any reason shall not affect any rights and duties of either party accrued prior to termination and the following Clauses shall continue to be enforceable: Clauses 4 (confidentiality), 5 (data protection), 8 (intellectual property), 9 (publication), 10.4 (destruction of Data), 10.5 (survival), 11 (costs), 12 (legal statement). 11. COSTS 11.1 Within thirty (30) days of a request by Crick, the Recipient shall pay any costs reasonably incurred (including administrative costs and costs associated with obtaining appropriate data storage devices) by Crick in providing the Data. 12. LEGAL STATEMENT 13. Neither Crick nor any party or individual involved in the creation, collation, protection or original analysis of the Data: (a) makes any warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of the Data; (b) shall have any liability for any action, claim, proceeding, demand, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of the Data, or from the unavailability of, or break in access to the Data for whatever reason. 13.2. The Recipient hereby indemnifies Crick, and its officers, agents and employees, against all claims, procedures, loss, damages, costs and expenses (including legal costs and expenses) whether successful or otherwise, arising out of any use or application by the Recipient of any of the Data or any breach of this agreement by the Recipient or any Researcher. This indemnity shall survive the termination of this agreement for any reason. The persons identified in this paragraph may enforce the rights granted to them under it. 14. GENERAL 14.1. Time shall not be of the essence in respect of any of Crick’s obligations under this agreement, and Crick shall have no liability of any kind caused directly or indirectly by any delay in delivery of, or failure to deliver, the Data. 14.2. This agreement (and any dispute of any nature related to it or its formation) shall be construed, interpreted and governed by English law. The parties submit to the exclusive jurisdiction of the English courts. Signatures on following page   AGREED by the parties through their authorised signatories For and on behalf of Francis Crick Institute: Name (print): Position: Signed: Date: For and on behalf of the Recipient: Authorised Signatory’s name(print): Authorised Signatory’s position: Signed: Date: Address: Telephone number: Email address: Schedule Authorised User - Registration Form I have read and understood the contents of the agreement between Crick and [insert the Recipient’s name] dated [insert date] and will comply with the Recipient’s obligations under the agreement when using the Data. Name:(printed) Signed: Position: Date: Address: Telephone number: Email address: Research (describe): Completed forms to be sent to: Professor Charlie Swanton The Francis Crick Institute 1 Midland Road London, NW1 1AT United Kingdom

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001003484 Other
ID File Type Size Located in
EGAF00002399106 bam 2.7 GB
EGAF00002399107 bam 3.5 GB
EGAF00002399108 bam 2.1 GB
EGAF00002399109 bam 4.4 GB
EGAF00002399110 bam 3.5 GB
EGAF00002399111 bam 3.5 GB
EGAF00002399112 bam 3.1 GB
EGAF00002399113 bam 3.6 GB
EGAF00002399114 bam 1.7 GB
EGAF00002399115 bam 2.5 GB
EGAF00002399116 bam 2.8 GB
EGAF00002399117 bam 6.1 GB
EGAF00002399118 bam 6.2 GB
EGAF00002399119 bam 5.4 GB
EGAF00002399120 bam 4.8 GB
EGAF00002399121 bam 4.3 GB
EGAF00002399122 bam 4.5 GB
EGAF00002399123 bam 5.4 GB
EGAF00002399124 bam 4.0 GB
EGAF00002399125 bam 3.8 GB
EGAF00002399126 bam 5.0 GB
EGAF00002399127 bam 5.6 GB
EGAF00002399128 bam 4.5 GB
EGAF00002399129 bam 4.0 GB
EGAF00002399130 bam 3.8 GB
EGAF00002399131 bam 2.1 GB
EGAF00002399132 bam 4.3 GB
EGAF00002399133 bam 4.2 GB
EGAF00002399134 bam 2.6 GB
EGAF00002399135 bam 3.7 GB
EGAF00002399136 bam 3.3 GB
EGAF00002399137 bam 2.7 GB
EGAF00002399138 bam 3.2 GB
EGAF00002399139 bam 2.4 GB
EGAF00002399140 bam 3.0 GB
EGAF00002399141 bam 3.6 GB
EGAF00002399142 bam 3.4 GB
EGAF00002399143 bam 2.5 GB
EGAF00002399144 bam 4.7 GB
EGAF00002399145 bam 2.5 GB
EGAF00002399146 bam 3.5 GB
EGAF00002399147 bam 5.3 GB
EGAF00002399148 bam 5.0 GB
EGAF00002399149 bam 3.3 GB
EGAF00002399150 bam 3.9 GB
EGAF00002399151 bam 4.4 GB
EGAF00002399152 bam 4.2 GB
EGAF00002399153 bam 6.3 GB
EGAF00002399154 bam 5.0 GB
EGAF00002399155 bam 4.4 GB
EGAF00002399156 bam 3.1 GB
EGAF00002399157 bam 2.5 GB
EGAF00002399158 bam 2.3 GB
EGAF00002399159 bam 2.1 GB
EGAF00002399160 bam 1.9 GB
EGAF00002399161 bam 4.1 GB
EGAF00002399162 bam 6.7 GB
EGAF00002399163 bam 4.1 GB
EGAF00002399164 bam 5.6 GB
EGAF00002399165 bam 4.0 GB
EGAF00002399166 bam 6.6 GB
EGAF00002399167 bam 6.0 GB
EGAF00002399168 bam 7.3 GB
EGAF00002399169 bam 5.2 GB
EGAF00002399170 bam 7.3 GB
EGAF00002399171 bam 4.4 GB
EGAF00002399172 bam 5.8 GB
EGAF00002399173 bam 6.0 GB
EGAF00002399174 bam 4.7 GB
EGAF00002399175 bam 9.1 GB
EGAF00002399176 bam 3.7 GB
EGAF00002399177 bam 1.5 GB
EGAF00002399178 bam 4.6 GB
EGAF00002399179 bam 4.9 GB
EGAF00002399180 bam 5.6 GB
EGAF00002399181 bam 4.9 GB
EGAF00002399182 bam 5.7 GB
EGAF00002399183 bam 7.9 GB
EGAF00002399184 bam 6.2 GB
EGAF00002399185 bam 4.6 GB
EGAF00002399186 bam 5.7 GB
EGAF00002399187 bam 8.1 GB
EGAF00002399188 bam 6.8 GB
EGAF00002399189 bam 5.7 GB
EGAF00002399190 bam 7.8 GB
EGAF00002399191 bam 6.0 GB
EGAF00002399192 bam 4.2 GB
EGAF00002399193 bam 3.0 GB
EGAF00002399194 bam 2.6 GB
EGAF00002399195 bam 2.8 GB
EGAF00002399196 bam 3.3 GB
EGAF00002399197 bam 3.5 GB
EGAF00002399198 bam 3.0 GB
EGAF00002399199 bam 3.8 GB
EGAF00002399200 bam 3.6 GB
EGAF00002399201 bam 4.9 GB
EGAF00002399202 bam 4.7 GB
EGAF00002399203 bam 7.4 GB
98 Files (429.3 GB)