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Chromatin 3D interactions mediate genetic effects on gene expression

Studying the genetic basis of gene expression and chromatin organization is key to characterize the effect of genetic variability on the function and structure of the human genome. Here, we unravel how genetic variation perturbs gene regulation using a dataset combining activity of regulatory elements, gene expression and genetic variants across 317 individuals and two cell types.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001004790 251
EGAD00001004871 Illumina HiSeq 2000 239
EGAD00001004872 Illumina HiSeq 2000 246
Publications Citations
A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation.
Nat Commun 13: 2022 2042
Disentangling genetic effects on transcriptional and post-transcriptional gene regulation through integrating exon and intron expression QTLs.
Nat Commun 15: 2024 3786