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Genomic Signatures Reveal DNA Damage Response Deficiency in Brain Metastases of Colorectal Cancer

Brain metastasis (BM) of colorectal cancer (CRC) is rare but lethal, and lacks effective therapies or a good understanding of its genomic landscapes. We conduct an analysis of whole-exome sequencing (WES) and whole-genome sequencing (WGS) data on 19 trios of patient-matched BMs, primary CRC tumors, and adjacent normal tissue to (1) document genomic signatures during the evolution of CRC BM; (2) identify clinically actionable targets for the BM treatment; and (3) identify potential drivers in CRC BM.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001005030 38
Publications Citations
Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases.
Nat Commun 10: 2019 3190