Study
Genomic, transcriptomic and epigenomic profiling of GCTB
| Study ID | Alternative Stable ID | Type |
|---|---|---|
| EGAS00001003730 | Other |
Study Description
Giant cell tumor of bone is a rare bone neoplasm driven by oncogenic hotspot G34W/L/V mutations in the non-canonical histone variant H3.3. This study provides primary data of genomic (WGS), transcriptomic (RNA-seq) and epigenomic (histone mark ChIP-seq, WGBS, ATAC-seq) profiling of primary GCTB samples from several cohorts in Germany and Korea. We confirm the H3.3-G34 mutations as sole genetic drivers of GCTB, and describe the epigenetic alterations in mutant GCTB stromal cells.
Study Datasets 1 dataset.
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| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00001005109 |
This dataset contains primary raw data of whole-genome sequencing, whole-genome bisulfite sequencing, ATAC-seq, ChIP-seq (ChIP-mentation) of histone variants and modifications, as well as RNA-seq of giant cell tumor of bone tissue and primary cell line samples.
|
HiSeq X Ten,Illumina HiSeq 2000 | 29 |
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