Celiac disease meta-analysis
Celiac disease (CeD) is a common immune-mediated disease of the small intestine that is triggered by exposure to dietary gluten. While the HLA locus plays a major role in disease susceptibility, 39 non-HLA loci were also identified in a study of 24,269 individuals. We now build on this earlier study by adding 4,125 additional Caucasian samples including an Argentinian cohort genotyped on the Immunochip. In doing so, we not only confirm the previous associations, we also identify two novel independent genome-wide significant associations.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
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Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease.
Eur J Hum Genet 28: 2020 313-323
Systematic Prioritization of Candidate Genes in Disease Loci Identifies <i>TRAFD1</i> as a Master Regulator of IFNγ Signaling in Celiac Disease.
Front Genet 11: 2020 562434