Celiac disease meta-analysis

Celiac disease (CeD) is a common immune-mediated disease of the small intestine that is triggered by exposure to dietary gluten. While the HLA locus plays a major role in disease susceptibility, 39 non-HLA loci were also identified in a study of 24,269 individuals. We now build on this earlier study by adding 4,125 additional Caucasian samples including an Argentinian cohort genotyped on the Immunochip. In doing so, we not only confirm the previous associations, we also identify two novel independent genome-wide significant associations.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

9 Datasets 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00010001763	Association results from Polish cohort	Immunochip	1062
EGAD00010001764	Association results from the Dutch cohort	Immunochip	3378
EGAD00010001765	Association results from Spanish cohort	Immunochip	2325
EGAD00010001766	Association results fromthe Agentinian cohort two	Immunochip	465
EGAD00010001767	Association results from British cohort	Immunochip	16002
EGAD00010001768	Association results from the Agentinian cohort one	Immunochip	741
EGAD00010001769	Association results from the Irish cohort	Immunochip	848
EGAD00010001770	Results of the celiac diease meta-analysis	Immunochip	27786
EGAD00010001771	Association results from the Italian cohort	Immunochip	2965

Publications	Citations
Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease. Ricaño-Ponce I, Gutierrez-Achury J, Costa AF, Deelen P, Kurilshikov A, Zorro MM, Platteel M, van der Graaf A, Consortium for the study of genetic associations of celiac disease in Latin-America, Sanna S, Daffra O, Zhernakova A, Fu J, Trynka G, Smecuol E, Niveloni SI, Bai JC, Kumar V, Wijmenga C. Eur J Hum Genet 28: 2020 313-323	8
Systematic Prioritization of Candidate Genes in Disease Loci Identifies <i>TRAFD1</i> as a Master Regulator of IFNγ Signaling in Celiac Disease. van der Graaf A, Zorro MM, Claringbould A, Võsa U, Aguirre-Gamboa R, Li C, Mooiweer J, Ricaño-Ponce I, Borek Z, Koning F, Kooy-Winkelaar Y, Sollid LM, Qiao SW, Kumar V, Li Y, Franke L, Withoff S, Wijmenga C, Sanna S, Jonkers I, BIOS Consortium. Front Genet 11: 2020 562434	16

Publications

Citations

Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease.
Ricaño-Ponce I, Gutierrez-Achury J, Costa AF, Deelen P, Kurilshikov A, Zorro MM, Platteel M, van der Graaf A, Consortium for the study of genetic associations of celiac disease in Latin-America, Sanna S, Daffra O, Zhernakova A, Fu J, Trynka G, Smecuol E, Niveloni SI, Bai JC, Kumar V, Wijmenga C. Eur J Hum Genet 28: 2020 313-323

Systematic Prioritization of Candidate Genes in Disease Loci Identifies <i>TRAFD1</i> as a Master Regulator of IFNγ Signaling in Celiac Disease.
van der Graaf A, Zorro MM, Claringbould A, Võsa U, Aguirre-Gamboa R, Li C, Mooiweer J, Ricaño-Ponce I, Borek Z, Koning F, Kooy-Winkelaar Y, Sollid LM, Qiao SW, Kumar V, Li Y, Franke L, Withoff S, Wijmenga C, Sanna S, Jonkers I, BIOS Consortium. Front Genet 11: 2020 562434