Need Help?

Celiac disease meta-analysis

Celiac disease (CeD) is a common immune-mediated disease of the small intestine that is triggered by exposure to dietary gluten. While the HLA locus plays a major role in disease susceptibility, 39 non-HLA loci were also identified in a study of 24,269 individuals. We now build on this earlier study by adding 4,125 additional Caucasian samples including an Argentinian cohort genotyped on the Immunochip. In doing so, we not only confirm the previous associations, we also identify two novel independent genome-wide significant associations.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010001763 Immunochip 1062
EGAD00010001764 Immunochip 3378
EGAD00010001765 Immunochip 2325
EGAD00010001766 Immunochip 465
EGAD00010001767 Immunochip 16002
EGAD00010001768 Immunochip 741
EGAD00010001769 Immunochip 848
EGAD00010001770 Immunochip 27786
EGAD00010001771 Immunochip 2965
Publications Citations
Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease.
Eur J Hum Genet 28: 2020 313-323
Systematic Prioritization of Candidate Genes in Disease Loci Identifies <i>TRAFD1</i> as a Master Regulator of IFNγ Signaling in Celiac Disease.
Front Genet 11: 2020 562434