Activation of IL7RA signalling in human B-lymphoid precursors induces pre-leukemia

Study ID Alternative Stable ID Type
EGAS00001003979 Cancer Genomics

Study Description

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
There are two samples, 42 (control) and 49 To test the role of activated CRLF2/IL7RA in leukemia initiation we expressed CRLF2 together with IL7RA in human CB hematopoietic progenitors. Human CRLF2 and wild type and/or activated mutant form of human IL7RA (IL7RAwt/ins) were cloned into a lentiviral vector with a bi-cistronic cassette under the expression control of an Eμ-B29 promoter/enhancer to augment expression in B-cell precursors. Backbone vector expressing GFP (BB). Whole genome ... (Show More)
Illumina HiSeq 2500 2

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