Imaging metabolic heterogeneity in breast cancer using hyperpolarized 13C-MRI

Study ID Alternative Stable ID Type
EGAS00001004118 Other

Study Description

Higher 13C-lactate labeling was seen in the more aggressive tumors, including all triple negative breast cancers. There was a significant correlation between lactate labeling and expression of the monocarboxylate transporter (MCT1), which mediates tumor cell pyruvate uptake, and a weaker correlation with expression of LDHA, which catalyzes label exchange between the injected pyruvate and the endogenous lactate pool.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Transcriptomics for samples obtained from six patients (MBR01, MBR03, MBR05, MBR07, MBR10, MBR11)
Illumina HiSeq 2500 14

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