Imaging metabolic heterogeneity in breast cancer using hyperpolarized 13C-MRI
|Study ID||Alternative Stable ID||Type|
Higher 13C-lactate labeling was seen in the more aggressive tumors, including all triple negative breast cancers. There was a significant correlation between lactate labeling and expression of the monocarboxylate transporter (MCT1), which mediates tumor cell pyruvate uptake, and a weaker correlation with expression of LDHA, which catalyzes label exchange between the injected pyruvate and the endogenous lactate pool.
Study Datasets 2 datasets.
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Transcriptomics for samples obtained from six patients (MBR01, MBR03, MBR05, MBR07, MBR10, MBR11)
|Illumina HiSeq 2500||14|
Transcriptomic data for five patients with breast cancer undergoing neoadjuvant chemotherapy and hyperpolarised 13C-MRI for early response assessment
|Illumina HiSeq 2500||10|
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