Imaging metabolic heterogeneity in breast cancer using hyperpolarized 13C-MRI

Study

Study ID	Alternative Stable ID	Type
EGAS00001004118		Other

Study Description

Higher 13C-lactate labeling was seen in the more aggressive tumors, including all triple negative breast cancers. There was a significant correlation between lactate labeling and expression of the monocarboxylate transporter (MCT1), which mediates tumor cell pyruvate uptake, and a weaker correlation with expression of LDHA, which catalyzes label exchange between the injected pyruvate and the endogenous lactate pool.

Study Datasets 2 datasets.

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Dataset ID	Description	Technology	Samples
EGAD00001005760	Transcriptomics for samples obtained from six patients (MBR01, MBR03, MBR05, MBR07, MBR10, MBR11) Transcriptomics for samples obtained from six patients (MBR01, MBR03, MBR05, MBR07, MBR10, MBR11)	Illumina HiSeq 2500	14
EGAD00001008141	Transcriptomic data for five patients with breast cancer undergoing neoadjuvant chemotherapy and hyperpolarised 13C-MRI for early response assessment Transcriptomic data for five patients with breast cancer undergoing neoadjuvant chemotherapy and hyperpolarised 13C-MRI for early response assessment	Illumina HiSeq 2500	10

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