Single cell RNA-seq profiling of CD8 T cells from elder adults

Single cell RNA-seq profiling of ~62k purified CD8+ T cell transcriptomes, from six healthy older adult donors using 10X genomics. Cells from each donor were separated based on their IL-7R protein expression (i.e. CD8+ IL7R+ and CD8+ IL7R- T cells).

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001006000	Single cell RNA-seq profiling of ~62k purified CD8+ T cell transcriptomes, from six healthy older adult donors using 10X genomics. Cells from each donor were separated based on their IL-7R protein expression (i.e. CD8+ IL7R+ and CD8+ IL7R- T cells).	Illumina HiSeq 4000	12

Publications	Citations
Sestrins induce natural killer function in senescent-like CD8<sup>+</sup> T cells. Pereira BI, De Maeyer RPH, Covre LP, Nehar-Belaid D, Lanna A, Ward S, Marches R, Chambers ES, Gomes DCO, Riddell NE, Maini MK, Teixeira VH, Janes SM, Gilroy DW, Larbi A, Mabbott NA, Ucar D, Kuchel GA, Henson SM, Strid J, Lee JH, Banchereau J, Akbar AN. Nat Immunol 21: 2020 684-694	101
Heterogeneity and transcriptome changes of human CD8<sup>+</sup> T cells across nine decades of life. Lu J, Ahmad R, Nguyen T, Cifello J, Hemani H, Li J, Chen J, Li S, Wang J, Achour A, Chen J, Colie M, Lustig A, Dunn C, Zukley L, Chia CW, Burd I, Zhu J, Ferrucci L, Weng NP. Nat Commun 13: 2022 5128	10