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Epigenetic analyses of methylation and nucleosome occupancy in cell-free DNA (cfNOMe)

Cell-free DNA (cfDNA) has become essential in cancer diagnostics and prenatal testing. We investigate enzymatic cytosine conversion for epigenetic analyses of cfDNA and find that it reliably measures cytosine methylation and nucleosome occupancy. Whereas previously, separate experiments had to be performed to study either epigenetic marking, this approach delivers reliable results for both, enabling more comprehensive and inexpensive epigenetic profiling of cfDNA.

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Dataset ID Description Technology Samples
EGAD00001006072 Illumina NovaSeq 6000 45
Publications Citations
cfNOMe - A single assay for comprehensive epigenetic analyses of cell-free DNA.
Genome Med 12: 2020 54