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Methylation and nucleosome occupancy studies on cell-free DNA using enzymatic cytosine conversion

Raw sequencing data (PE, fastq.gz) from NovaSeq 6000 sequencing runs of: 1. Blood-derived cell-free DNA from six healthy controls, enzymatic cytosine conversion (between 1 and 3 replicates each) 2. Urine-derived cell-free DNA from three healthy controls, enzymatic cytosine conversion (between 1 and 3 replicates each) 3. Blood-derived cell-free DNA from six patients with acute or chronic kidney disease with/without other relevant organ dysfunction, enzymatic cytosine conversion (between 1 and 3 replicates each) 4. Urine-derived cell-free DNA from three patients with acute kidney disease, enzymatic cytosine conversion (between 1 and 3 replicates each) 5. Blood-derived cell-free DNA from three healthy controls, bisulfite cytosine conversion (single datasets) 6. Conventional whole-genome sequencing on genomic DNA of two healthy kidney donors for two of the studied patients (single datasets).

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General data access policy, Cologne Rare Kidney Diseases Research Group.

In the interest of our research participants, the datasets deposited in EGA by the Cologne Rare Kidney Diseases Research Group can only be shared after an application for access has been approved by our Data Access Committee. In order to gain data access approval, researchers must agree to keep the requested data secure and use it only for the approved purposes. The Cologne Rare Kidney Diseases Research Group Data Access Committee will individually review requests for access to data stored at the EGA. Requests must contain the following details: The principal applicant’s name, title, position, affiliation, email address, institutional website and mailing address. The name, title, position, affiliation, email address and mailing address of the applicant’s institutional representative, if applicable. The name, title, position, affiliation, and email address of any personnel or students who need access to the data. Any other information needed for unique authentication of the applicant, personnel and students. A scientific abstract providing a brief (approx. 500-word) overview of the research to be carried out, including the proposed uses of the data requested. A list of references to other works by the applicant in the relevant research field, if applicable. A letter of ethics approval for the proposed research project. A detailed description of the data security safeguards and access controls under which any and all requested data will be stored at the applicant's institution. If access to the requested data is granted, we ask that any substantive use of the data in research publications be appropriately acknowledged and/or cited, e.g.: This research used data shared by the Cologne Rare Kidney Diseases Research Group, available from the European Genome-phenome Archive of the European Bioinformatics Institute (accession numbers: study EGAS... and dataset(s) EGAD....

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001004370 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00003599791 fastq.gz 21.4 GB
EGAF00003599792 fastq.gz 22.6 GB
EGAF00003599793 fastq.gz 18.1 GB
EGAF00003599794 fastq.gz 19.2 GB
EGAF00003599795 fastq.gz 22.8 GB
EGAF00003599796 fastq.gz 24.2 GB
EGAF00003599797 fastq.gz 19.0 GB
EGAF00003599798 fastq.gz 20.2 GB
EGAF00003599799 fastq.gz 87.6 GB
EGAF00003599800 fastq.gz 90.2 GB
EGAF00003599801 fastq.gz 29.6 GB
EGAF00003599802 fastq.gz 31.5 GB
EGAF00003599803 fastq.gz 22.2 GB
EGAF00003599804 fastq.gz 23.9 GB
EGAF00003599805 fastq.gz 24.0 GB
EGAF00003599806 fastq.gz 26.2 GB
EGAF00003599807 fastq.gz 24.9 GB
EGAF00003599808 fastq.gz 26.5 GB
EGAF00003599809 fastq.gz 24.6 GB
EGAF00003599810 fastq.gz 26.3 GB
EGAF00003599811 fastq.gz 36.8 GB
EGAF00003599812 fastq.gz 39.7 GB
EGAF00003599813 fastq.gz 22.9 GB
EGAF00003599814 fastq.gz 24.4 GB
EGAF00003599815 fastq.gz 35.5 GB
EGAF00003599816 fastq.gz 38.1 GB
EGAF00003599817 fastq.gz 16.5 GB
EGAF00003599818 fastq.gz 17.6 GB
EGAF00003599819 fastq.gz 73.5 GB
EGAF00003599820 fastq.gz 77.8 GB
EGAF00003599821 fastq.gz 24.6 GB
EGAF00003599822 fastq.gz 25.3 GB
EGAF00003599823 fastq.gz 23.4 GB
EGAF00003599824 fastq.gz 24.1 GB
EGAF00003599825 fastq.gz 26.1 GB
EGAF00003599826 fastq.gz 26.3 GB
EGAF00003599827 fastq.gz 20.4 GB
EGAF00003599828 fastq.gz 21.2 GB
EGAF00003599829 fastq.gz 22.7 GB
EGAF00003599830 fastq.gz 25.4 GB
EGAF00003599831 fastq.gz 15.8 GB
EGAF00003599832 fastq.gz 17.0 GB
EGAF00003599833 fastq.gz 51.0 GB
EGAF00003599834 fastq.gz 53.3 GB
EGAF00003599835 fastq.gz 57.5 GB
EGAF00003599836 fastq.gz 60.6 GB
EGAF00003599837 fastq.gz 51.2 GB
EGAF00003599838 fastq.gz 54.6 GB
EGAF00003599839 fastq.gz 28.4 GB
EGAF00003599840 fastq.gz 30.5 GB
EGAF00003599841 fastq.gz 26.1 GB
EGAF00003599842 fastq.gz 27.6 GB
EGAF00003599843 fastq.gz 33.9 GB
EGAF00003599844 fastq.gz 36.1 GB
EGAF00003599845 fastq.gz 24.5 GB
EGAF00003599846 fastq.gz 25.9 GB
EGAF00003599847 fastq.gz 67.8 GB
EGAF00003599848 fastq.gz 73.1 GB
EGAF00003599849 fastq.gz 38.1 GB
EGAF00003599850 fastq.gz 39.5 GB
EGAF00003599851 fastq.gz 28.5 GB
EGAF00003599852 fastq.gz 29.3 GB
EGAF00003599853 fastq.gz 26.6 GB
EGAF00003599854 fastq.gz 28.3 GB
EGAF00003599855 fastq.gz 31.8 GB
EGAF00003599856 fastq.gz 33.0 GB
EGAF00003599857 fastq.gz 28.1 GB
EGAF00003599858 fastq.gz 30.2 GB
EGAF00003599859 fastq.gz 17.1 GB
EGAF00003599860 fastq.gz 17.9 GB
EGAF00003599861 fastq.gz 18.7 GB
EGAF00003599862 fastq.gz 19.9 GB
EGAF00003599863 fastq.gz 24.1 GB
EGAF00003599864 fastq.gz 25.4 GB
EGAF00003599865 fastq.gz 17.3 GB
EGAF00003599866 fastq.gz 18.3 GB
EGAF00003599867 fastq.gz 19.9 GB
EGAF00003599868 fastq.gz 20.9 GB
EGAF00003599869 fastq.gz 32.1 GB
EGAF00003599870 fastq.gz 33.7 GB
EGAF00003599871 fastq.gz 32.5 GB
EGAF00003599872 fastq.gz 34.0 GB
EGAF00003599873 fastq.gz 19.0 GB
EGAF00003599874 fastq.gz 19.5 GB
EGAF00003599875 fastq.gz 23.1 GB
EGAF00003599876 fastq.gz 24.1 GB
EGAF00003599877 fastq.gz 21.1 GB
EGAF00003599878 fastq.gz 22.2 GB
EGAF00003599879 fastq.gz 21.7 GB
EGAF00003599880 fastq.gz 23.1 GB
90 Files (2.8 TB)