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Immunogenomic landscape of hematological malignancies

We integrated over 8,000 transcriptomes and over 2,000 samples with multilevel genomic data of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival. For more detailed follow-up analyses in acute myeloid leukemia (AML), single-cell RNA sequencing was performed on 8 AML bone marrow samples at diagnosis to profile the phenotypes of blasts and infiltrating immune cells in different disease subtypes.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006173 Illumina HiSeq 2500 Illumina NovaSeq 6000 128
Publications Citations
Patient-tailored design for selective co-inhibition of leukemic cell subpopulations.
Sci Adv 7: 2021 eabe4038