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Peripheral immunoprofiling of stratifies COVID-19 patients based on disease-specific neutrophil signatures

The SARS-CoV-2 pandemic has led to increasing numbers of COVID-19 patients all over the world. Aetiopathologies range from no symptoms, mild flu-like to severe cases succumbing to respiratory failure. Reports on a dysregulated immune system in the severe cases, showing similarities to cytokine release syndrome, calls for better characterization and understanding of the changes in the immune system as well as their variance across COVID-19 patients in order to be able to design according to host-directed therapies. Here, we profiled blood transcriptomes of 39 COVID-19 patients and 10 control donors. Enriched granulocyte signatures in whole blood samples were verified in granulocyte samples from 49 COVID-19 patients in a second cohort.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006326 NextSeq 500 79
EGAD00001006671 NextSeq 500 41
Publications Citations
Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection.
Mol Ther Methods Clin Dev 20: 2021 109-121
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Genome Med 13: 2021 7
Upregulation of oxidative stress gene markers during SARS-COV-2 viral infection.
Free Radic Biol Med 172: 2021 688-698
Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection.
Front Immunol 12: 2021 686462
Upregulation of interleukin-19 in saliva of patients with COVID-19.
Sci Rep 12: 2022 16019
Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.
Cell Rep 42: 2023 112525