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Hydroxycarbamide effect on DNA methylation and gene expression in MPN patients

Hydroxycarbamide (HC), is a cytoreductive drug frequently used to control cell blood counts in patients with myeloproliferative neoplasms (MPNs).To further explore the effects of HC in MPN patients, we performed DNA methylation and gene expression profiling of two differentially developed and clinically relevant cell types, both before and following HC exposure.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006330 Illumina HiSeq 4000 16
EGAD00010001940 Illumina MethylationEPIC BeadChip 31
EGAD00010001941 Illumina MethylationEPIC BeadChip 4
Publications Citations
Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms.
Genome Res 31: 2021 1381-1394