Hydroxycarbamide effect on DNA methylation and gene expression in MPN patients

Study ID Alternative Stable ID Type
EGAS00001004583 Other

Study Description

Hydroxycarbamide (HC), is a cytoreductive drug frequently used to control cell blood counts in patients with myeloproliferative neoplasms (MPNs).To further explore the effects of HC in MPN patients, we performed DNA methylation and gene expression profiling of two differentially developed and clinically relevant cell types, both before and following HC exposure.

Study Datasets 3 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
Whole RNA-sequencing of CD34+ cells and neutrophils derived from MPN patients before hydroxycarbamide treatment and after 9-months of treatment. CD34+ cells= 5 patients, 10 samples; neutrophils= 7 patients, 14 samples. Fastq files provided.
Illumina HiSeq 4000 16
DNA methylation measures on neutrophils
Illumina MethylationEPIC BeadChip 31
DNA methylation measures on CD34 cells
Illumina MethylationEPIC BeadChip 4

Who archives the data?