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RRBS MDACC Lung PreCancer

To study the evolution of DNA methylation at genome level and methylation intra-tumor heterogeneity (ITH) during early lung carcinogenesis, we performed multiregional reduced representation bisulfite sequencing (RRBS) of 62 resected lung nodules from 39 patients including atypical adenomatous hyperplasia (AAH, n=14), adenocarcinoma in situ (AIS, n=15), minimally invasive adenocarcinoma (MIA, n=22), and invasive adenocarcinoma (ADC, n=11).

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006367 127
Publications Citations
Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas.
Nat Commun 12: 2021 687
Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features.
Nat Commun 12: 2021 2722