Differential gene expression in the colon mucosa of irritable bowel syndrome patients with mixed type symptoms

The aim of this study is to characterize the pathophysiology of the irritable bowel syndrome (IBS) on the functional level and in parallel on the gene expression level. For this purpose RNAseq of mucosal biopsies was performed. The data from the differential expression analysis will be further processed by Ingenuity Pathway Analysis (IPA) software to gather Information on activated or inhibited signaling pathways in the disease.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001006646	The data set consists of fastq raw files from RNA-seq of seven mucosal biopsies of the colon from seven patients, among them three patients with irritable bowel syndrome with mixed type symptoms. Paired end sequencing on Illumina NovaSeq 6000 was used.	Illumina NovaSeq 6000	7
EGAD50000000063	The data set consists of fastq raw files from RNA-seq of seven mucosal biopsies of the colon from seven patients, among them three patients with irritable bowel syndrome with diarrhea-predominant symptoms. Paired end sequencing on Illumina NovaSeq 6000 was used.	Illumina NovaSeq 6000	8

Publications	Citations
Impaired Intestinal Permeability of Tricellular Tight Junctions in Patients with Irritable Bowel Syndrome with Mixed Bowel Habits (IBS-M). Awad K, Barmeyer C, Bojarski C, Nagel O, Lee IM, Schweiger MR, Schulzke JD, Bücker R. Cells 12: 2023 236	7
Epithelial Barrier Dysfunction in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) via Downregulation of Claudin-1. Awad K, Barmeyer C, Bojarski C, Nagel O, Lee IM, Schweiger MR, Schulzke JD, Bücker R. Cells 12: 2023 2846	1